AI Article Synopsis
- Research suggests that abnormalities in white matter (WM) are linked to schizophrenia, with polyunsaturated fatty acids (PUFAs) possibly affecting myelination and showing reduced levels in those with the disorder.
- A study involving 30 male patients with a recent psychotic disorder found that lower total PUFA concentrations correlated with decreased white matter integrity, measured through diffusion tensor imaging.
- The results indicate that lower levels of specific PUFAs, like arachidonic acid, are associated with both reduced WM integrity and increased severity of negative symptoms, highlighting the potential for PUFA supplementation to improve outcomes in early psychosis.
Article Abstract
Background: White matter (WM) abnormalities have been implicated in schizophrenia, yet the mechanisms underlying these abnormalities are not fully understood. Several lines of evidence suggest that polyunsaturated fatty acids (PUFAs) play a role in myelination, and there is substantial evidence documenting decreased PUFA concentrations in schizophrenia. We therefore hypothesized that lower membrane PUFA concentrations may be related to reduced WM integrity in schizophrenia and related disorders.
Methods: In 30 male patients with a recent-onset psychotic disorder, erythrocyte membrane PUFA concentrations were assessed and diffusion tensor imaging was performed with voxelwise analysis.
Results: Lower total PUFA concentration was associated with lower fractional anisotropy (FA) throughout the corpus callosum and bilateral parietal, occipital, temporal and frontal WM (P < .05, corrected). Of the individual PUFAs, lower arachidonic acid concentration, and to a lesser extent, lower nervonic acid, linoleic acid, and docosapentaenoic acid concentration were significantly associated with lower FA. PUFA concentrations were inversely associated with radial diffusivity but showed little association with axial diffusivity. Greater severity of negative symptoms was associated with lower nervonic acid concentration and lower FA values.
Conclusions: Membrane PUFA concentrations appear to be robustly related to brain WM integrity in early phase psychosis. These findings may provide a basis for studies to investigate the effects of PUFA supplementation on WM integrity and associated symptomatology in early psychosis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686450 | PMC |
| http://dx.doi.org/10.1093/schbul/sbs089 | DOI Listing |
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