AI Article Synopsis
- Chemokine-dependent trafficking is crucial for T cell function in immune responses, and this study highlights the role of aquaporin-3 (AQP3) in T cell migration during skin immune reactions.
- AQP3 helps T cells uptake hydrogen peroxide (H(2)O(2)), which is necessary for activating the Cdc42 protein and influencing actin dynamics, rather than just transporting water or glycerol.
- Mice lacking AQP3 show impaired T cell movement to the skin in response to allergens, demonstrating that AQP3's H(2)O(2) uptake is vital for effective T cell migration during immune responses.
Article Abstract
Chemokine-dependent trafficking is indispensable for the effector function of antigen-experienced T cells during immune responses. In this study, we report that the water/glycerol channel aquaporin-3 (AQP3) is expressed on T cells and regulates their trafficking in cutaneous immune reactions. T cell migration toward chemokines is dependent on AQP3-mediated hydrogen peroxide (H(2)O(2)) uptake but not the canonical water/glycerol transport. AQP3-mediated H(2)O(2) transport is essential for the activation of the Rho family GTPase Cdc42 and the subsequent actin dynamics. Coincidentally, AQP3-deficient mice are defective in the development of hapten-induced contact hypersensitivity, which is attributed to the impaired trafficking of antigen-primed T cells to the hapten-challenged skin. We therefore suggest that AQP3-mediated H(2)O(2) uptake is required for chemokine-dependent T cell migration in sufficient immune response.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457725 | PMC |
| http://dx.doi.org/10.1084/jem.20112398 | DOI Listing |
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