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Electrocardiographic marker of ventricular action potential triangulation (the simulation study).
J Electrocardiol
December 2024
Physiology Unit, Department of Pre-Clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine Campus, Mount Hope Hospital, Building 35, Uriah Butler Highway, Trinidad and Tobago.
Background: The aim of this simulation was to examine the utility of a novel ECG-based index of cardiac action potential (AP) triangulation, the Tstart-to-Tpeak (TsTp) interval-to-JTstart (JTs) interval ratio, for assessment of changes in AP profile imposed through variations in the duration of the plateau phase and the phase 3 repolarization.
Methods: ECGs were simulated using a realistic rabbit model based on experimental data. The AP plateau was measured at APD30, and the phase 3 was assessed as APD90-to-APD30 difference (AP durations at 90 % and 30 % repolarization, respectively).
Cardiovascular problems in rabbits in reference to hypothyroidism - a four-year retrospective study.
Pol J Vet Sci
December 2024
Department of Epizootiology and the Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Głęboka 30, 20-612 Lublin, Poland.
The effects of T4 are mainly manifested by positive ino- and chronotropism. The syndrome accompanying hypothyroidism in rabbits (impaired myocardial contractility and reduced ejection capacity) is caused by a deficiency of thyroid hormones - especially T4. The study group consisted of a total of 41 animals: 15 males and 26 females, ranging in age from 2 months to 8 years, with echocardiogram showing reduced fractional shortening (<30%), with normal results of heamatological and biochemical tests.
View Article and Find Full Text PDFThe adjuvant effect of manganese on tuberculosis subunit vaccine Bfrb-GrpE.
NPJ Vaccines
December 2024
Key Laboratory of Blood-stasis-toxin Syndrome of Zhejiang Province, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Protein subunit vaccines, lacking pathogen-associated molecular patterns that trigger immune responses, rely on adjuvants to induce robust immune responses against the target pathogen. Thus, selection of adjuvants plays a crucial role in the design of protein subunit vaccines. Recently, there has been growing interest in utilizing cGAS-STING agonists as vaccine adjuvants.
View Article and Find Full Text PDFRabbit Gastroenterology.
Vet Clin North Am Exot Anim Pract
December 2024
Zoo, Exotic and Wildlife Medicine, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada; Small Animal Clinical Sciences Department, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada.
Gastrointestinal (GI) disorders are a common cause of emergency presentation in rabbits. Gastrointestinal stasis is a syndrome that is frequently caused by various primary conditions (including but not limited to affections of the GI tract itself). Over the last years, clinical features, diagnosis, management, and prognosis of GI disorders-such as GI obstructions, appendicitis, rabbit hemorrhagic virus disease, or liver lobe torsion-have been studied.
View Article and Find Full Text PDFDevelopment of a seroepidemiological tool for bat-borne and shrew-borne hantaviruses and its application using samples from Zambia.
PLoS Negl Trop Dis
November 2024
Graduate School of Infectious Diseases, Hokkaido University, Sapporo, Japan.
Background: Rodent-borne orthohantaviruses are the causative agents of hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Apart from the classic rodent-borne hantaviruses, numerous species of hantaviruses have been identified in shrews and bats; however, their antigenicity and pathogenicity are unknown. This study focused on developing a serological method to detect antibodies against bat- and shrew-borne hantaviruses.
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