AI Article Synopsis
- Historical data from rabbit prenatal developmental toxicity studies (1994-2010) was collected from 20 labs in Japan, including pharmaceutical companies and contract labs.
- The studies primarily involved Japanese White and New Zealand White rabbits focusing on maternal and fetal outcomes at cesarean sections.
- No significant differences in reproductive and developmental data were found between rabbit strains or labs; however, variations in fetal alterations were attributed to different observation criteria and terminologies used by the labs.
Article Abstract
Historical control data on rabbit prenatal developmental toxicity studies, performed between 1994-2010, were obtained from 20 laboratories, including 11 pharmaceutical and chemical companies and nine contract laboratories, in Japan. In this paper, data were incorporated from a laboratory if the information was based on 10 studies or more. Japanese White rabbits and New Zealand White rabbits were used for prenatal developmental toxicity studies. The data included maternal reproductive findings at terminal cesarean sections and fetal findings including spontaneous incidences of morphological alterations. No noticeable differences between strains or laboratories were observed in the maternal reproductive and fetal developmental data. The inter-laboratory variations in the incidences of fetal external, visceral, and skeletal alterations seem to be due to differences in the selection of observation parameters, observation criteria, and classification of the findings, and terminology of fetal alterations.
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| http://dx.doi.org/10.1111/j.1741-4520.2012.00365.x | DOI Listing |
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