Collagenous fibroma (desmoplastic fibroblastoma) is a distinctive yet uncommon fibrous soft tissue tumor. These tumors are rather nondescript in their morphological appearance and have been diagnosed as fibromas or some other benign mesenchymal lesions for years. The most common sites are the upper extremities, followed by the lower extremities. Rare lesions arise in the head and neck region. We report a rare case in the oral cavity and present its unique histopathological features (central fat entrapment) besides others, and diffusely strong vimentin immunopositivity.
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| http://dx.doi.org/10.4103/0973-029X.99089 | DOI Listing |
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An Unusual Case of Intraosseous Desmoplastic Fibroblastoma (Collagenous Fibroma) of the Mandible.
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Desmoplastic fibroblastoma (collagenous fibroma) is a rare, benign fibroblastic/myofibroblastic tumor that usually arises in the subcutaneous and intramuscular tissues. This tumor type has rarely been described to arise primarily in bones. This is a case of intraosseous desmoplastic fibroblastoma occurring in the mandible of a 35-year-old woman that was detected incidentally during a routine dental examination.
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Background/aim: Desmoplastic fibroblastoma, also known as collagenous fibroma, is a rare benign mesenchymal neoplasm that primarily arises in the subcutaneous tissue of upper extremities and limb girdles. The knee is an uncommon location for desmoplastic fibroblastoma. Recent studies have demonstrated the presence of immunoreactivity for FOS like 1 (FOSL1) and rearrangements of FOSL1.
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