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Functional traits mediate the effect of land use on drivers of community stability within and across trophic levels.
Sci Adv
January 2025
Forest Entomology, Swiss Federal Research Institute WSL, Birmensdorf, Switzerland.
Understanding how land use affects temporal stability is crucial to preserve biodiversity and ecosystem functions. Yet, the mechanistic links between land-use intensity and stability-driving mechanisms remain unclear, with functional traits likely playing a key role. Using 13 years of data from 300 sites in Germany, we tested whether and how trait-based community features mediate the effect of land-use intensity on acknowledged stability drivers (compensatory dynamics, portfolio effect, and dominant species variability), within and across plant and arthropod communities.
View Article and Find Full Text PDFSonographer Experiences of Interprofessional Ultrasound Education: A Qualitative Study.
J Contin Educ Health Prof
January 2025
Ms. Cormack: Adjunct Senior Lecturer, Medical Imaging and Radiation Sciences Department, Faculty of Medicine, Nursing and Health Sciences, Monash University, and PhD Candidate, Education Portfolio, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia.
Introduction: Point-of-care ultrasound (POCUS) technology has evolved rapidly and is being embraced by many health professionals as a valuable clinical tool. Sonographers are now teaching ultrasound skills to other health professionals in the clinical setting, including doctors, nurses, midwives, paramedics, and physiotherapists. The purpose of this study was to understand the breadth of the opportunities, transitions, and challenges experienced by sonographer educators navigating new interprofessional teaching roles.
View Article and Find Full Text PDFRecent advances in synthetic biology toolkits and metabolic engineering of Ralstonia eutropha H16 for production of value-added chemicals.
Biotechnol Adv
January 2025
State Key Laboratory of Synthetic Biology, and School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; College of Life and Health Sciences, Northeastern University, Shenyang 110169, China. Electronic address:
Ralstonia eutropha H16, a facultative chemolithoautotrophic Gram-negative bacterium, demonstrates remarkable metabolic flexibility by utilizing either diverse organic substrates or CO as the sole carbon source, with H serving as the electron donor under aerobic conditions. The capacity of carbon and energy metabolism of R. eutropha H16 enabled development of synthetic biology technologies and strategies to engineer its metabolism for biosynthesis of value-added chemicals.
View Article and Find Full Text PDFUsing routine primary care data in research: (in)efficient case studies and perspectives from the Asthma UK Centre for Applied Research.
BMJ Health Care Inform
January 2025
College of Medicine and Veterinary Medic, The University of Edinburgh Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK.
Aim: We aimed to identify enablers and barriers of using primary care routine data for healthcare research, to formulate recommendations for improving efficiency in knowledge discovery.
Background: Data recorded routinely in primary care can be used for estimating the impact of interventions provided within routine care for all people who are clinically eligible. Despite official promotion of 'efficient trial designs', anecdotally researchers in the Asthma UK Centre for Applied Research (AUKCAR) have encountered multiple barriers to accessing and using routine data.
Parkinson's Disease Pathogenic Variants: Cross-Ancestry Analysis and Microarray Data Validation.
medRxiv
December 2024
Integrative Neurogenomics Unit (INU), Laboratory of Neurogenetics, National Institutes of Health, Bethesda, USA.
Background: Known pathogenic variants in Parkinson's disease (PD) contribute to disease development but have yet to be fully explored by arrays at scale.
Objectives: This study evaluated genotyping success of the NeuroBooster array (NBA) and determined the frequencies of pathogenic variants across ancestries.
Method: We analyzed the presence and allele frequency of 34 pathogenic variants in 28,710 PD cases, 9,614 other neurodegenerative disorder cases, and 15,821 controls across 11 ancestries within the Global Parkinson's Genetics Program dataset.
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