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Elevation of spectral components of electrodermal activity precedes central nervous system oxygen toxicity symptoms in divers.
Commun Med (Lond)
December 2024
Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
Background: Oxygen-rich breathing mixtures up to 100% are used in some underwater diving operations for several reasons. Breathing elevated oxygen partial pressures (PO) increases the risk of developing central nervous system oxygen toxicity (CNS-OT) which could impair performance or result in a seizure and subsequent drowning. We aimed to study the dynamics of the electrodermal activity (EDA) and heart rate (HR) while breathing elevated PO in the hyperbaric environment (HBO) as a possible means to predict impending CNS-OT.
View Article and Find Full Text PDFUtility of N-acetylcysteine in Non-Acetaminophen-Induced Liver Injury Secondary to Influenza A Infection.
Cureus
October 2024
Family Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, USA.
Influenza A, which belongs to the Orthomyxoviridae viral family, is a known causative agent of respiratory illness and systemic inflammation. Annual influenza immunizations are crucial in reducing the incidence and severity of the flu. Intravenous (IV) N-acetylcysteine (NAC) is a pharmaceutical agent indicated for hepatic injury, particularly to address oxidative stress and inflammation secondary to acetaminophen toxicity.
View Article and Find Full Text PDFDevelopment of chromone-thiazolidine-2,4-dione Knoevenagel conjugates as apoptosis inducing agents.
Bioorg Med Chem Lett
September 2024
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India. Electronic address:
Overexpression of Bcl-2 protein is a predominant hallmark of disturbed apoptotic pathway in most of the cancers. Herein, chromone-linked thiazolidinediones were designed and synthesized to target Bcl-2 for regulating anti-apoptotic proteins. The study on in vitro cancer cell lines revealed the presence of compounds 8a, 8k, 8l, and 8n, which were found to have good to moderate anti-proliferative activity (with an IC concentration less than 10 µM).
View Article and Find Full Text PDFZinc oxide/graphene oxide nanocomposites specifically remediated Cd-contaminated soil via reduction of bioavailability and ecotoxicity of Cd.
Sci Total Environ
August 2024
School of Environmental Science and Optoelectronic Technology, University of Science and Technology of China, Hefei 230026, PR China; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, CAS, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, CAS, Hefei, Anhui, 230031, PR China; Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, PR China. Electronic address:
From both environment and health perspectives, sustainable management of ever-growing soil contamination by heavy metal is posing a serious global concern. The potential ecotoxicity of cadmium (Cd) to soil and ecosystem seriously threatens human health. Developing efficient, specific, and long-term remediation technology for Cd-contaminated soil is impending to synchronously minimize the bioavailability and ecotoxicity of Cd.
View Article and Find Full Text PDFAzathioprine/hydroxyurea preconditioning prior to nonmyeloablative matched sibling donor hematopoietic stem cell transplantation in adults with sickle cell disease: A prospective observational cohort study.
Am J Hematol
August 2024
Department of Hematology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Nonmyeloablative, matched sibling donor hematopoietic stem cell transplantation with alemtuzumab/total body irradiation (TBI) conditioning is a curative therapy with low toxicity for adults with sickle cell disease (SCD). However, relatively low donor chimerism levels and graft rejection remain important challenges. We hypothesized that adding azathioprine/hydroxyurea preconditioning will improve donor chimerism levels and reduce graft failure rate.
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