AI Article Synopsis
- Autoimmune thyroid disease (AITD), which includes conditions like Graves' disease and Hashimoto's thyroiditis, is a common immune-mediated disorder.
- Researchers used a specialized SNP array called the ImmunoChip to study genetic factors linked to AITD, analyzing over 100,000 SNPs among patients and controls.
- Their findings revealed seven new risk loci associated with AITD, contributing to the understanding of genetic influences on these autoimmune diseases.
Article Abstract
Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490518 | PMC |
| http://dx.doi.org/10.1093/hmg/dds357 | DOI Listing |
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