AI Article Synopsis
- Changes in MCHR1 expression are linked to obesity and anxiety disorders.
- Positron emission tomography (PET) is effective for monitoring these conditions in living organisms.
- The synthesis of a new PET tracer, [(18)F]FE@SNAP, was achieved using a successful direct fluorination method in a flow-through microreactor.
Article Abstract
Changes in the expression of the melanin concentrating hormone receptor 1 (MCHR1) are involved in a variety of pathologies, especially obesity and anxiety disorders. To monitor these pathologies in-vivo positron emission tomography (PET) is a suitable method. After the successful radiosynthesis of [(11)C]SNAP-7941-the first PET-Tracer for the MCHR1, we aimed to synthesize its [(18)F]fluoroethylated analogue: [(18)F]FE@SNAP. Therefore, microfluidic and vessel-based approaches were tested. [(18)F]fluoroethylation was conducted via various [(18)F]fluoroalkylated synthons and direct [(18)F]fluorination. Only the direct [(18)F]fluorination of a tosylated precursor using a flow-through microreactor was successful, affording [(18)F]FE@SNAP in 44.3 ± 2.6%.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460236 | PMC |
| http://dx.doi.org/10.1016/j.bmc.2012.07.051 | DOI Listing |
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