Purpose: The purpose was to describe the magnetic resonance imaging appearance of the brain and spine in a patient.
Method: A patient with pancreatitis and neurologic findings is described.
Results: Our patient had an inflammatory condition involving the pancreas and orbital muscles, a constellation of findings that should suggest systemic IgG-related disease (SIRD).
Conclusions: Patients with multiorgan inflammatory disease, especially those involving the pancreas and other organs, should be evaluated for possible SIRD.
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| http://dx.doi.org/10.1016/j.clinimag.2011.12.012 | DOI Listing |
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Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice.
J Allergy Clin Immunol
April 2017
Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, Paris, France; INSERM, U1222, Paris, France. Electronic address:
Background: Anaphylaxis can proceed through distinct IgE- or IgG-dependent pathways, which have been investigated in various mouse models. We developed a novel mouse strain in which the human low-affinity IgG receptor locus, comprising both activating (hFcγRIIA, hFcγRIIIA, and hFcγRIIIB) and inhibitory (hFcγRIIB) hFcγR genes, has been inserted into the equivalent murine locus, corresponding to a locus swap.
Objective: We sought to determine the capabilities of hFcγRs to induce systemic anaphylaxis and identify the cell types and mediators involved.
Case report of systemic IgG-related disease affecting the pancreas and orbit.
Clin Imaging
February 2013
Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7510, USA.
Purpose: The purpose was to describe the magnetic resonance imaging appearance of the brain and spine in a patient.
Method: A patient with pancreatitis and neurologic findings is described.
Results: Our patient had an inflammatory condition involving the pancreas and orbital muscles, a constellation of findings that should suggest systemic IgG-related disease (SIRD).
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