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Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma.

Cells

December 2024

Institute of Anaesthesiologic Pathophysiology and Process Development, University Hospital Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany.

Article Synopsis
  • Traumatic brain injury (TBI) is a leading cause of death, complicating the development of effective therapies due to the unique nature of each injury.
  • Clinical questions regarding the benefits of measuring intracranial pressure, cerebral perfusion pressure, and surgical interventions remain largely unanswered.
  • This study focused on acute subdural hematoma in a porcine model to better understand secondary brain injury and the effects of different injury patterns on outcomes, highlighting the need for comprehensive models to improve TBI treatment translation.
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Background: Little is known about long-term outcomes beyond survival following acute aortic dissection. The aim of this research was to evaluate rates of home care initiation and nursing home admission during the first year after discharge and to assess factors associated with these needs.

Methods: All patients in Denmark with a first-time diagnosis of acute aortic dissection type A or B between 2006 and 2015 were identified using national registries.

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Background: ERAS is an evidence-based multimodal perioperative protocol focused on stress reduction and promoting a return to function. The aim of this work is to perform a cost-consequence analysis for the implementation of ERAS in major lung resection by means of minimally invasive surgery (VATS) from the public health service perspective, evaluating resource consumption and clinical outcomes with respect to a control group of past patients, which did not adopt an ERAS protocol.

Methods: Outcome differences (re-intervention rates, major and minor intraoperative and postoperative complications, readmissions, and mortality) as well as the costs of preoperative, operative, and postoperative care were estimated.

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[Not Available].

Ugeskr Laeger

September 2024

Afdeling for Anæstesi og Intensiv Medicin, Sjællands Universitetshospital, Roskilde.

A new national treatment guideline from Danish Society of Anaesthesiology and Intensive Care Medicine (DASAIM) outlines the anaesthetic management of pre-eclampsia and eclampsia. Key principles involve blood pressure control, seizure treatment and prophylaxis, and restricted fluid therapy. Treatment algorithms, flow charts and checklists are provided.

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Article Synopsis
  • The study investigates the surgical outcomes of elderly patients with lumbar disc herniation who are on antithrombotic medications, focusing on the challenges posed by their cardiovascular history.
  • A total of 163 patients were analyzed, categorized into groups based on their antithrombotic management strategies before undergoing surgery.
  • Findings indicate that surgical procedures can be safely performed without significant differences in intraoperative outcomes or complications across the different medication management approaches.
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