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Importance: The effectiveness of different approaches to dementia care is unknown.
Objective: To determine the effectiveness of health system-based, community-based dementia care, and usual care for persons with dementia and for caregiver outcomes.
Design, Setting, And Participants: Randomized clinical trial of community-dwelling persons living with dementia and their caregivers conducted at 4 sites in the US (enrollment June 2019-January 2023; final follow-up, August 2023).
Emotional and Behavioural Adjustment in Children and Adolescents with Short Stature vs. Their Normal-Statured Peers.
J Clin Med
January 2025
Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 28824 Piancavallo-Verbania, Italy.
: the aim of the current cross-sectional study is to explore and compare the emotional and behavioural conditions of children and adolescents with short stature (i.e., familial short stature and constitutional delay of growth), idiopathic growth hormone deficiency (GHD), and normal height.
View Article and Find Full Text PDFA randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome.
J Neurodev Disord
January 2025
Rett Syndrome Research Trust, Trumbull, CT, USA.
Background: Preclinical studies and anecdotal case reports support the potential therapeutic benefit of low-dose oral ketamine as a treatment of clinical symptoms in Rett syndrome (RTT); however, no controlled studies have been conducted in RTT to evaluate safety, tolerability and efficacy.
Design: This was a sequentially initiated, dose-escalating cohort, placebo-controlled, double blind, randomized sequence, cross-over study of oral ketamine in 6-12-year-old girls with RTT to evaluate short-term safety and tolerability and explore efficacy.
Methods: Participants were randomized to either five days treatment with oral ketamine or matched placebo, followed by a nine-day wash-out period and then crossed-over to the opposite treatment.
A Novel Custom Bent 27-Gauge Needle-Guided Suture Snare Technique for Scleral Fixation of Posterior Chamber Intraocular Lenses.
Retina
February 2025
Department of Ophthalmology, Liyang Hospital of Chinese Medicine, Liyang, China.
Purpose: To describe a custom bent 27-gauge needle-guided suture snare technique for scleral fixation of posterior chamber intraocular lenses (PCIOL).
Methods: An 8-0 polypropylene suture was threaded into the lumen of a custom bent 27-gauge needle, and the needle tip was advanced into the eye from the intraocular lens (IOL) fixation point. The suture was threaded through the posterior limbal incision inside the IOL haptic loop and pulled out.
Association between anti-seizure medications and cardiac arrhythmias in patients undergoing ambulatory electroencephalographic and electrocardiographic monitoring.
Seizure
January 2025
Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, 29 Regent Street, Fitzroy VIC 3065, Australia; Seer Medical, Melbourne, Victoria, Australia; Department of Neurology, St Vincent's Hospital Melbourne, 41 Victoria Parade Fitzroy VIC 3065, Australia.
Background Anti-seizure medications (ASMs) are commonly prescribed in epilepsy. However some have been associated with adverse cardiac outcomes including cardiac arrhythmias. Methods We conducted an observational study evaluating patients aged ≥16 years undergoing ambulatory video - electroencephalographic (EEG) - electrocardiographic (ECG) monitoring (AVEEM) between 2020 and 2023 in Australia.
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