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| http://dx.doi.org/10.1089/apc.2012.0199 | DOI Listing |
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Changes to inflammatory markers during 5 years of viral suppression and during viral blips in people with HIV initiating different integrase inhibitor based regimens.
Front Immunol
November 2024
Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, United States.
Background: Heightened levels of inflammatory markers are linked to increased morbidity/mortality in people with HIV (PWH) and often remain elevated after virologic suppression by antiretroviral therapy (ART). As new combinations of ART become available, an evaluation of their effects on immune activation and inflammation is warranted. Additionally, it remains unknown whether transient increases in viral load ("blips") during ART are associated with increases in inflammation.
View Article and Find Full Text PDFPreferences for oral and injectable PrEP among qualitative sub-study participants in HPTN 084.
PLoS One
October 2024
Wits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Background: HPTN 084 compared the safety and efficacy of long-acting injectable cabotegravir (CAB) to daily oral TDF/FTC for prevention of HIV-1 in uninfected African women. Like a similar trial in MSM/TGW (HPTN 083), the trial was stopped early for efficacy, expediting the need to consider introduction strategies for different populations. We examine survey and qualitative data from a four-country sub-study to examine oral and injectable PrEP acceptability and considerations for CAB access among African women.
View Article and Find Full Text PDFA case series of intermittent nucleoside analogue-based (NA) regimen to maintain HBV virological suppression in coinfected HBV/HIV patients with suppressed viremia.
Infect Dis Now
October 2024
Sorbonne University, Infectious Diseases Department, Pitié-Salpêtrière Hospital, AP-HP, Pierre Louis Epidemiology and Public Health institute (iPLESP), INSERM 1136, Paris, France.
Objective: To describe the efficacy of intermittent nucleoside analogue-based (NA) regimen to maintain HBV virological suppression in HBV/HIV-1 patients.
Methods: Conducted between 2014 and 2023, this observational retrospective study included all HBV (positive AgHbs)/HIV-1 coinfected patients with HIV RNA ≤ 50 cp/mL and HBV DNA ≤ 25 UI/mL who were switched to an intermittent (<7/7 days(D)) TDF or TAF-containing antiretroviral (ART) regimen. The primary outcome was the HBV virological success rate (SR) (proportion of patients with HBV pVL < 25 UI/mL) at W48.
Background: This study aimed to investigate factors contributing to non-sustained viral suppression, including intermittent viremia and persistent low-level viremia, during cabotegravir (CAB) plus rilpivirine (RPV) long-acting (LA) injectable therapy, with a focus on pharmacokinetics (PK).
Methods: A prospective cohort study was conducted on people with HIV (PWH) transitioning from stable oral antiretroviral therapy (ART) to bimonthly CAB+RPV LA. Standardized follow-up included close monitoring through blood sampling for plasma HIV-1 viral load (VL) and multiple plasma drug concentrations measurements to analyze the connection between PK parameters and virologic outcomes.
Consequences of low-level viremia among women with HIV in the United States.
AIDS
November 2024
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine.
Article Synopsis
- The study aimed to explore the health outcomes of women with HIV who have low-level viremia (LLV), focusing on virologic failure and the development of non-AIDS comorbidities.
- Researchers analyzed data from the Women's Interagency HIV Study, categorizing women based on their viral load status into groups: virologic suppression, intermittent LLV, persistent LLV, and virologic failure.
- Results indicated that women with intermittent or persistent LLV had a higher risk of virologic failure compared to those with virologic suppression, with persistent LLV showing a tendency towards increased risk for multiple health issues.
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