AI Article Synopsis
- Remifentanil is a synthetic opioid known for its ultrashort action, quickly broken down by enzymes in the body.
- Its unique metabolism leads to a steady and predictable duration of effect, making it useful in anesthesia and pain relief.
- However, there are concerns about its potential for causing tolerance and increased sensitivity to pain, which limits its effectiveness for long-term pain management.
Article Abstract
Remifentanil is an ultrashort-acting synthetic opioid. It is metabolized by nonspecific tissue and plasma esterases. Remifentanil's metabolism is responsible for its unique pharmacokinetic profile and flat, context-sensitive half-time. Since its introduction into clinical practice, remifentanil has been used for a variety of anesthetic and analgesic applications; however, concerns regarding a potential for rapid induction of tolerance and/or induced hyperalgesia, coupled with an ultrarapid offset of effect, make the drug less than optimal for use in the pharmacologic management of pain.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417946 | PMC |
| http://dx.doi.org/10.2147/lra.s7709 | DOI Listing |
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