AI Article Synopsis
- Increased risk for metabolic syndrome is associated with psychotic disorders, potentially worsened by antipsychotic medications like haloperidol and clozapine.
- A 12-week study on Sprague Dawley rats showed that clozapine led to significant weight gain and elevated glucose and lipid levels, while haloperidol resulted in reduced weight and increased insulin levels.
- Both medications produced different metabolic effects based on sex, suggesting that they may influence metabolic syndrome risk factors like hyperinsulinemia and hyperglycemia.
Article Abstract
Introduction: An increased risk for metabolic syndrome has been described for patients with psychotic disorders. Antipsychotic drugs possibly contribute to metabolic changes.
Methods: Haloperidol or clozapine was orally fed to male and female Sprague Dawley rats for 12 weeks, and body weight gain, food and water intake were measured. The serum levels of fasting glucose, HbA1c, triglycerides, cholesterol, HDL and LDL, insulin, leptin, adiponectin and ghrelin were determined. Gonadal and perirenal fat pads were removed and weighed.
Results: We found increased body weight in the male clozapine group, but decreased ones in the male haloperidol group. Clozapine-treated male and female animals had higher fasting glucose, adiponectin, leptin, ghrelin, cholesterol, HDL and LDL levels, whereas haloperidol caused increased levels of insulin and decreased values of HbA1c, cholesterol, HDL and LDL.
Conclusion: Both antipsychotic drugs cause sex-dependent metabolic changes, which are risk factors for the metabolic syndrome, be it hyperinsulinemia under haloperidol treatment or hyperglycemia, hyperleptinemia and hyperlipidemia under clozapine.
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| http://dx.doi.org/10.1055/s-0032-1321907 | DOI Listing |
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