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Polymorphism G80A in the reduced folate carrier gene and its relationship to survival and risk of relapse in acute lymphoblastic leukemia. | LitMetric

AI Article Synopsis

  • - The study investigates the G80A polymorphism in the RFC1 gene, a key transporter for methotrexate, and its impact on survival and relapse in patients with acute lymphoblastic leukemia (ALL).
  • - Results show that patients with the G/A and A/A genotypes have significantly higher relapse rates (3.97 and 7.84 times more likely, respectively) and poorer survival outcomes compared to other genotypes.
  • - The findings indicate that the G80A polymorphism contributes to relapse risk and mortality in ALL patients, highlighting its potential significance in treatment and prognosis, particularly in those from Guerrero, Mexico.

Article Abstract

Background: The reduced folate carrier (RFC1) is a major methotrexate transporter whose impaired function was recognized as a frequent mechanism of antifolate resistance. Recently, a G80A polymorphism has been described in the RFC1. This study evaluated the effect of the G80A polymorphism in the RFC1 gene on survival and risk of relapse of acute lymphoblastic leukemia.

Methods And Results: Seventy patients with acute lymphoblastic leukemia were genotyped by polymerase chain reaction restriction fragment length polymorphism method. An association between the polymorphism and risk of relapse was found (P < 0.05). Patients with the G/A genotype have 3.97 (95% confidence interval, 1.12-14.06) and carriers of the A/A genotype have 7.84 (95% confidence interval, 1.66-37.10) higher chance of a relapse. Other variables such as age and leukocyte count were associated (P < 0.05) with the risk of relapse of disease. Individuals with G/A or A/A genotypes had poorer survival (log-rank test, P = < 0.05).

Conclusions: These data suggest a role of the polymorphism G80A in the risk of relapse and the mortality risk in patients with acute lymphoblastic leukemia from the State of Guerrero, Mexico.

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Source
http://dx.doi.org/10.2310/JIM.0b013e31826803c1DOI Listing

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