AI Article Synopsis
- Pharmacogenetics is focused on personalizing medical treatments by analyzing genetic variations that affect how drugs work in the body and how they're processed.
- This review highlights significant genetic variations in metabolic enzymes and explores methods for identifying these variations through genetic testing or assessing how the body responds to specific drug tests (phenotyping).
- It emphasizes various analytical techniques that can be applied to measure the rate of drug metabolism in individuals.
Article Abstract
Pharmacogenetics is a rapidly developing field of science promising individualization of treatment through determination of genetic polymorphism in pharmacodynamics (receptors and other drug targets) and pharmacokinetics (carriers, metabolic enzymes). Enzyme activity may be predicted using genotyping or directly phenotyped - after administration of a probe substrate. This review article deals with some important metabolic enzyme polymorphisms and their phenotyping methods. Special consideration is given to the analytical methods described in the literature, which can be used to determine the metabolic rate.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!