A highly efficient and stereoselective arylation of in situ-generated azavinyl carbenes affording 2,2-diaryl enamines at ambient temperatures has been developed. These transition-metal carbenes are directly produced from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of a rhodium carboxylate catalyst. In several cases, the enamines generated in this reaction can be cyclized into substituted indoles employing copper catalysis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597238 | PMC |
| http://dx.doi.org/10.1021/ja3062453 | DOI Listing |
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