PloS one

1932-6203772012PloS onePLoS OneEpidemiologic and economic burden of influenza in the outpatient setting: a prospective study in a subtropical area of China.e41403e41403e4140310.1371/journal.pone.0041403To understand the incidence of outpatient influenza cases in a subtropical area of China and the associated economic burden on patients' families.A hospital-based prospective study was conducted in Zhuhai City during 2008-2009. All outpatient influenza-like illness (ILI) cases were identified in 28 sentinel hospitals. A representative sample of throat swabs from ILI cases were collected for virus isolation using Madin-Darby canine kidney cells. The incidence of outpatient influenza cases in Zhuhai was estimated on the basis of the number of influenza patients detected by the sentinel sites. A telephone survey on the direct costs associated with illness was conducted as a follow-up.The incidence of influenza was estimated to be 4.1 per 1,000 population in 2008 and 19.2 per 1,000 population in 2009. Children aged <5 years were the most-affected population, suffering from influenza at the highest rates (34.3 per 1,000 population in 2008 and 95.3 per 1,000 population in 2009). A high incidence of 29.2-40.9 per 1000 population was also seen in young people aged 5-24 years in 2009. ILI activity and influenza virus isolations adopted a consistent seasonal pattern, with a summer peak in July 2008 and the longest epidemic period lasting from July-December 2009. The medical costs per episode of influenza among urban patients were higher than those for rural patients. A total of $1.1 million in direct economic losses were estimated to be associated with outpatient influenza during 2008-2009 in Zhuhai community.Influenza attacks children aged <5 years in greater proportions than children in other age groups. Seasonal influenza 2008 and Pandemic influenza A (H1N1) 2009 had different epidemiological and etiological characteristics. Direct costs (mostly medical costs) impose an enormous burden on the patient family. Vaccination strategies for high-risk groups need to be further strengthened.GuoRu-ningRNInstitute of Infectious Disease Prevention and Control, Center for Disease Control and Prevention of Guangdong Province, Guangzhou, China.ZhengHui-zhenHZHuangLi-qunLQZhouYongYZhangXinXLiangChan-kunCKLinJin-yanJYHeJian-fengJFZhangJin-qingJQengJournal ArticleResearch Support, Non-U.S. Gov't20120720