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How does gut microbiota affect the vaginitis axis? The mediating role of plasma metabolites.
Microbiol Spectr
December 2024
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Vaginitis is the most common problem afflicting women of childbearing age. However, the underlying etiological factors remain poorly understood, leading to recurrent vaginitis and constraining clinical management. Here, we explored whether the gut microbiota influences the risk of vaginitis by performing a two-sample Mendelian randomization analysis using the largest genome-wide association studies to date.
View Article and Find Full Text PDFAssociation between serum iron status and gout: results from the NHANES and Mendelian randomization study.
Food Funct
January 2025
School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China.
. Previous observational studies have provided inconsistent evidence for the association between serum iron status and the risk of gout. Moreover, it remains uncertain whether the observed association is causal or due to confounding or reverse causality.
View Article and Find Full Text PDFCausal Effects of Valine on Ovarian Cancer: A Bidirectional Mendelian Randomization Analysis.
Nutr Cancer
January 2025
Department of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Background: Ovarian cancer is a lethal female cancer with a rising incidence that is often diagnosed late due to a lack of symptoms, affecting survival and quality of life. Studies suggest that dietary factors, especially the levels of branched-chain amino acids such as valine, may influence its development. While valine is essential for metabolism, its specific role in ovarian cancer remains unclear, necessitating further research.
View Article and Find Full Text PDFInfluence of vaccination against infectious diseases on the carbon footprint of fattening pigs: a systematic review.
Front Vet Sci
December 2024
Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Hanover, Germany.
Introduction: In all sectors of the economy, including livestock production, there is an increasing focus on sustainability criteria. The carbon footprint is therefore an important target value in pig production. The aim is to minimize this value.
View Article and Find Full Text PDFDeciphering the Prognostic Landscape of Esophageal Adenocarcinoma: A PANoptosis-Related Gene Signature.
J Cancer
January 2025
Department of Pathology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China.
Esophageal adenocarcinoma (EAC) remains a challenging malignancy with low survival rates despite advances in treatment. Understanding the molecular mechanisms and identifying reliable prognostic markers are crucial for improving clinical outcomes. We conducted a comprehensive bioinformatics analysis utilizing TCGA, GTEx, and GEO datasets to identify PANoptosis-related genes (PRGs) associated with EAC.
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