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Virus Association with Bacteria and Bacterial Cell Components Enhance Virus Infectivity.
Food Environ Virol
January 2025
Division of Agriculture, Department of Food Science, University of Arkansas, 1371 West Altheimer Dr, Fayetteville, AR, 72704, USA.
The transmission and infection of enteric viruses can be influenced by co-existing bacteria within the environment and host. However, the viral binding ligands on bacteria and the underlying interaction mechanisms remain unclear. This study characterized the association of norovirus surrogate Tulane virus (TuV) and murine norovirus (MNV) as well as the human enteric virus Aichi virus (AiV) with six bacteria strains (Pantoea agglomerans, Pantoea ananatis, Bacillus cereus, Enterobacter cloacae, Exiguobacterium sibiricum, Pseudomonas spp.
View Article and Find Full Text PDFPreparing Surrogates for Decision-Making: Development and Pilot Testing of PREPARE For THEIR Care.
J Pain Symptom Manage
January 2025
Division of Geriatrics, Department of Medicine, University of California, San Francisco, CA, USA; San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.
Context: Surrogate decision-makers have expressed the need for better preparation around communication and medical decision-making.
Objectives: This mixed-methods feasibility study aimed to assess the feasibility and usability of an online program to prepare surrogates for their role.
Methods: We developed a 2-part program for surrogates called PREPARE For THEIR Care with a diverse group of Community Advisory Board members and caregivers recruited from the National Patient Advocacy Foundation.
Modeling and the Use of Surrogate Endpoints: Is This a Valid Approach?
Dig Dis Sci
January 2025
Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands.
Background: Development of novel colorectal cancer (CRC) screening tests is a dynamic field. Decision analytic modeling based on inputs derived from rigorous prospective studies informs CRC screening guidelines. Exploratory modeling may have a place in early phases of test development.
View Article and Find Full Text PDFMulti-site, multi-vendor development and validation of a deep learning model for liver stiffness prediction using abdominal biparametric MRI.
Eur Radiol
January 2025
Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Background: Chronic liver disease (CLD) is a substantial cause of morbidity and mortality worldwide. Liver stiffness, as measured by MR elastography (MRE), is well-accepted as a surrogate marker of liver fibrosis.
Purpose: To develop and validate deep learning (DL) models for predicting MRE-derived liver stiffness using routine clinical non-contrast abdominal T1-weighted (T1w) and T2-weighted (T2w) data from multiple institutions/system manufacturers in pediatric and adult patients.
Serum Pentosidine in Relation to Obesity in Patients with Type 2 Diabetes and Healthy Controls.
Calcif Tissue Int
January 2025
Division of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Aeschenvorstadt 57, 4051, Basel, Switzerland.
Pentosidine (PEN), a surrogate marker of advanced glycation end-product formation, reflects increased non-enzymatic cross-linking in bone collagen, which is thought to be an important determinant of bone fragility in type 2 diabetes mellitus (T2DM). We aimed to investigate serum concentrations of PEN in patients with T2DM and controls without T2DM and to examine its relationship with bone parameters and metabolic state such as glycaemic control, insulin resistance and body weight. In a cross-sectional study-design, data from postmenopausal women and men with T2DM (n = 110) and controls without T2DM (n = 111) were evaluated.
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