AI Article Synopsis
- C(sp(3))-C(sp) bond formations are crucial in chemistry and material sciences, highlighting the need for effective methods in this area.
- The study presents a radical-mediated catalytic method using AgNO(3) as a catalyst and K(2)S(2)O(8) as an oxidant for C(sp(3))-C(sp) cross-coupling in mild aqueous conditions.
- This method allows for efficient decarboxylative alkynylation of various aliphatic carboxylic acids, demonstrating high compatibility with functional groups and remarkable chemo- and stereoselectivity.
Article Abstract
C(sp(3))-C(sp) bond formations are of immense interest in chemistry and material sciences. We report herein a convenient, radical-mediated and catalytic method for C(sp(3))-C(sp) cross-coupling. Thus, with AgNO(3) as the catalyst and K(2)S(2)O(8) as the oxidant, various aliphatic carboxylic acids underwent decarboxylative alkynylation with commercially available ethynylbenziodoxolones in aqueous solution under mild conditions. This site-specific alkynylation is not only general and efficient but also functional group compatible. In addition, it exhibits remarkable chemo- and stereoselectivity.
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| http://dx.doi.org/10.1021/ja306638s | DOI Listing |
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