We report the selection of Clostridium difficile resistant to the rifamycin class of antibiotics in a patient within 32 h of receiving rifaximin for the treatment of recurrent C. difficile diarrhea. Resistance was associated with single nucleotide substitutions within rpoB.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486587PMC
http://dx.doi.org/10.1128/AAC.00974-12DOI Listing

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