AI Article Synopsis
- Southwest Mexico City (SWMC) has higher levels of ozone and particulate matter (PM(10)), leading to increased myocardial inflammatory markers in young residents compared to those from the North.
- A study analyzing autopsy samples revealed significant up-regulation of inflammatory genes like IL-1β, TNF-α, and CD14 in the right ventricles of SWMC residents, indicating a pronounced inflammatory response.
- The findings suggest that living in areas with higher pollution levels may contribute to heart inflammation and potential cardiovascular issues in urban youth.
Article Abstract
Southwest Mexico City (SWMC) air pollution is characterized by high concentrations of ozone and particulate matter < 10 μm (PM(10)) containing lipopolysaccharides while in the North PM(2.5) is high. These intra-city differences are likely accounting for higher CD14 and IL-1β in SWMC v NMC mice myocardial expression. This pilot study was designed to investigate whether similar intra-city differences exist in the levels of myocardial inflammatory genes in young people. Inflammatory mediator genes and inflammasome arrays were measured in right and left autopsy ventricles of 6 southwest/15 north (18.5 ± 2.6 years) MC residents after fatal sudden accidental deaths. There was a significant S v N right ventricle up-regulation of IL-1β (p=0.008), TNF-α (p=0.001), IL-10 (p=0.001), and CD14 (p=0.002), and a left ventricle difference in TNF-α (p=0.007), and IL-10 (p=0.02). SW right ventricles had significant up-regulation of NLRC1, NLRP3 and of 29/84 inflammasome genes, including NOD factors and caspases. There was significant degranulation of mast cells both in myocardium and epicardial nerve fibers. Differential expression of key inflammatory myocardial genes and inflammasomes are influenced by the location of residence. Myocardial inflammation and inflammasome activation in young hearts is a plausible pathway of heart injury in urbanites and adverse effects on the cardiovascular system are expected.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392908 | PMC |
| http://dx.doi.org/10.1293/tox.25.163 | DOI Listing |
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