AI Article Synopsis
- Study aimed to improve bowel preparation for colonoscopy by using a prokinetic alongside split-dose polyethylene glycol (PEG), as standard PEG can leave residual fluid that hinders polyp detection.
- A prospective study randomly assigned patients to either receive prokinetics with PEG or PEG alone, measuring bowel cleansing effectiveness with the Ottawa scale and segmental fluidity scale.
- Results indicated that the group receiving prokinetics had significantly better bowel-cleansing scores, suggesting that combining prokinetics with PEG enhances the preparation quality for colonoscopies.
Article Abstract
Background/aims: Currently, a split-dose of polyethylene glycol (PEG) is the mainstay of bowel preparation due to its tolerability, bowel-cleansing action, and safety. However, bowel preparation with PEG is suboptimal because residual fluid reduces the polyp detection rate and requires a more thorough colon inspection. The aim of our study was to demonstrate the efficacy of a sufficient dose of prokinetics on bowel cleansing together with split-dose PEG.
Methods: A prospective endoscopist-blinded study was conducted. Patients were randomly allocated to two groups: prokinetic with split-dose PEG or split-dose PEG alone. A prokinetic [100 mg itopride (Itomed)], was administered twice simultaneously with each split-dose of PEG. Bowel-cleansing efficacy was measured by endoscopists using the Ottawa scale and the segmental fluidity scale score. Each participant completed a bowel preparation survey. Mean scores from the Ottawa scale, segmental fluid scale, and rate of poor preparation were compared between both groups.
Results: Patients in the prokinetics with split-dose PEG group showed significantly lower total Ottawa and segmental fluid scores compared with patients in the split-dose of PEG alone group.
Conclusion: A sufficient dose of prokinetics with a split-dose of PEG showed efficacy in bowel cleansing for morning colonoscopy, largely due to the reduction in colonic fluid.
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| http://dx.doi.org/10.1159/000339780 | DOI Listing |
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