The neutrophil-lymphocyte ratio (NLR) is an inflammatory marker of major adverse cardiac events (MACEs) in both acute coronary syndromes and stable coronary artery disease. The use of NLR as a predictive tool for MACEs among diabetic patients has not been elucidated. An observational study included 338 diabetic patients followed at our clinic between 2007 and 2011. Patients were arranged into equal tertiles according to the 2007 NLR. The MACEs included acute myocardial infarction, coronary revascularization, and mortality. The lowest NLR tertile (NLR < 1.6) had fewer MACEs compared with the highest NLR tertile (NLR > 2.36; MACEs were 6 of 113 patients vs 24 of 112 patients, respectively; P < .0001). In a multivariate model, the adjusted hazard ratio of third NLR tertile compared with first NLR tertile was 2.8 (95% confidence interval 1.12-6.98, P = .027). The NLR is a significant independent predictor of MACEs in diabetic patients. Further studies with larger numbers are needed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/0003319712455216 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Predictive Value of TyG Index and NLR for Risk of CHD and the Severity of Coronary Artery Lesions in Patients with Type 2 Diabetes Mellitus.
J Inflamm Res
December 2024
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Background: There is a paucity of research examining the Triglyceride-glucose (TyG) index and Neutrophil-to-lymphocyte ratio (NLR) in relation to the onset and severity of coronary heart disease (CHD) in individuals with type 2 diabetes mellitus (T2DM). This study aims to explore the relationship between these biomarkers and the risk of CHD in T2DM patients and clarify their association with the CHD severity.
Methods: A total of 518 patients with T2DM who underwent coronary angiography (CAG) were included and categorized into either the T2DM group or the T2DM combined with CHD group based on the angiographic findings.
The neutrophil-to-lymphocyte ratio is associated with in-hospital heart failure in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.
Heliyon
November 2024
Department of Cardiology, Linyi People's Hospital, Shandong Second Medical University, Linyi City, Shandong Province, 276000, China.
Objective: To explore the association between the neutrophil-to-lymphocyte ratio (NLR) and in-hospital heart failure (HF) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).
Methods: Our present study included 413 patients diagnosed with STEMI and treated with primary PCI. We performed logistic regression models to evaluate the relationship between the NLR and in-hospital HF risk in subjects diagnosed with STEMI.
Association Between the Neutrophil-to-Lymphocyte Ratio and in-Stent Neoatherosclerosis and Plaque Vulnerability: An Optical Coherence Tomography Study.
J Cardiovasc Pharmacol
November 2024
Department of Cardiology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
The aim of this study was to explore the relationship between in-stent neoatherosclerosis (ISNA) and the neutrophil-to-lymphocyte ratio (NLR) in patients with in-stent restenosis (ISR) following drug-eluting stent (DES) implantation. We divided 216 patients into 3 groups based on the NLR tertile. We performed a comparative analysis of baseline, angiographic, and features of optical coherence tomography (OCT) between the NLR groups and performed univariate and multivariate logistic regression analyses to assess the association of the NLR with ISNA and in-stent thin-cap fibroatheroma (TCFA).
View Article and Find Full Text PDFThe levels of systemic inflammatory markers exhibit a positive correlation with the occurrence of heart failure: a cross-sectional study from NHANES.
Front Cardiovasc Med
October 2024
Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, China.
Article Synopsis
- Researchers conducted a large-scale study to explore the link between inflammation markers and heart failure (HF) to potentially identify early detection biomarkers.
- They analyzed data from the National Health and Nutrition Examination Survey, focusing on five inflammation markers and found that increased levels were correlated with a higher risk of HF.
- The results showed significant increases in HF risk with elevated inflammation markers, except for the platelet to lymphocyte ratio, indicating a complex relationship useful for detecting HF.
Associations between inflammatory markers and carotid plaques in CKD: mediating effects of eGFR-a cross-sectional study.
BMC Nephrol
October 2024
Department of Nephrology, Zhongshan Hospital, Fudan University, No 180 Fenglin Rd., Shanghai, China.
Article Synopsis
- - The study examines the link between various inflammatory markers and the presence of carotid plaques in patients with chronic kidney disease (CKD), highlighting that these plaques are linked to heart disease and overall health risks.
- - A total of 609 patients were assessed, and after exclusions, 387 were analyzed to identify how inflammatory markers like SIRI, SII, and others affected the likelihood of developing carotid plaques.
- - Results showed that higher levels of specific inflammatory markers significantly increased the odds of carotid plaques, suggesting that monitoring these markers could help in managing CKD patients' cardiovascular risks.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!