The present study measured eight PBDE congeners' (BDE-28, 47, 99, 100, 153, 154, 183, and 209) exposure via ingestion of indoor dust and soil, inhalation, and food consumption. Contributions to PBDEs exposure from different media revealed that indoor dust (dust suspended in air) was not an important exposure route for PBDE congeners for adults in Shenzhen, China. Food consumption contributed more to daily intake of Σ(8)BDE, especially for lower-brominated PBDE congeners. Based on calculated average total daily intake, hazard quotients were determined to estimate the non-cancer risks of PBDE exposure. Meanwhile, cancer risk was also estimated assuming that the oral cancer slope factors of all PBDE congeners are equipotent as BDE-209. The hazard quotients ranged from 1.2×10(-5) (BDE-209) to 2.0×10(-2) (BDE-47), suggesting a low deleterious risk with regard to PBDEs. The cancer risk value ranged from 1.1×10(-24) to 5.5×10(-21) implying that the total risks due to exposure to PBDEs via all exposure routes are extremely low for adults.
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http://dx.doi.org/10.1016/j.scitotenv.2012.07.056 | DOI Listing |
Environ Toxicol Pharmacol
January 2025
Department of Biology, Sacred Heart University, Fairfield, CT, United States. Electronic address:
Polybrominated diphenyl ethers (PBDEs) are flame retardants heavily utilized across plastic, textile and electronic industries. Although these PBDEs are effective in protecting property and human life from fire, their high production volumes have led PBDEs to become pervasive environmental contaminants and pose an ecological and health risk as high levels have been noted in environmental media including water and sediment, wildlife and human tissue. Here we investigate the developmental neurotoxicity of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), one of the more dominant PBDE congeners found in human tissue, on oligodendrocytes in the hindbrain and spinal cord.
View Article and Find Full Text PDFAnn Agric Environ Med
December 2024
Department of Toxicology and Health Risk Assessment, National Institute of Public Health NIH / National Research Institute, Warsaw, Poland.
J Hazard Mater
December 2024
Department of Occupational and Environmental Health, MOE Key Laboratory of Environment and Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:
The brominated flame retardant 2, 2', 4, 4'-tetrabromodiphenyl ether (PBDE-47) is known as a developmental neurotoxicant, yet the underlying mechanisms remain unclear. This study aims to explore its neurotoxic mechanisms by integrating network toxicology with transcriptomics based on human neural precursor cells (hNPCs) and neuron-like PC12 cells. Network toxicology revealed that PBDE-47 crosses the blood-brain barrier more effectively than heavier PBDE congeners, and is associated with disruptions in 159 biological pathways, including cytosolic DNA-sensing pathway, ferroptosis, cellular senescence, and chemokine signaling pathway.
View Article and Find Full Text PDFChemosphere
February 2025
Bursa Technical University, Department of Environmental Engineering, Bursa, Turkiye. Electronic address:
The pollution potential of a municipal wastewater treatment plant (WWTP) in Bursa, Türkiye, in terms of organochlorine pesticides (ΣOCPs), polychlorinated biphenyls (ΣPCBs), and polybrominated diphenyl ethers (ΣPBDEs), was investigated in air samples. Concentrations were determined using polyurethane foam disk samplers at key processes, such as the aeration tank (AT) and settling chamber (SC) of the WWTP and the background area (BA) at an urban site. Atmospheric concentration levels of PBDEs at the SC are 1.
View Article and Find Full Text PDFSci Total Environ
January 2025
Osaka University, Research Center for Environmental Preservation, Japan.
The objective of this study was to analyze the concentrations of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in infant food (infant formulas and human milk) collected in Serbia and to assess their exposure and associated health risks. A total of 101 PCB congeners and 26 PBDE congeners were analyzed. In infant formulas (IF), the total PCB levels averaged 63.
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