AI Article Synopsis
- Alzheimer's disease (AD) affects brain connectivity, specifically reducing synchronization in certain areas like the medial temporal and frontal regions.
- A study compared 15 mild AD patients with 15 healthy controls, measuring brain activity through EEG over one year, revealing no overall change in synchronization.
- However, patients with rapidly progressing AD showed significant decreases in synchronization, particularly in the left frontotemporal cortex, suggesting EEG synchronization might serve as a cost-effective biomarker for monitoring AD progression.
Article Abstract
Alzheimer's disease (AD) disrupts functional connectivity in distributed cortical networks. We analyzed changes in the S-estimator, a measure of multivariate intraregional synchronization, in electroencephalogram (EEG) source space in 15 mild AD patients versus 15 age-matched controls to evaluate its potential as a marker of AD progression. All participants underwent 2 clinical evaluations and 2 EEG recording sessions on diagnosis and after a year. The main effect of AD was hyposynchronization in the medial temporal and frontal regions and relative hypersynchronization in posterior cingulate, precuneus, cuneus, and parietotemporal cortices. However, the S-estimator did not change over time in either group. This result motivated an analysis of rapidly progressing AD versus slow-progressing patients. Rapidly progressing AD patients showed a significant reduction in synchronization with time, manifest in left frontotemporal cortex. Thus, the evolution of source EEG synchronization over time is correlated with the rate of disease progression and should be considered as a cost-effective AD biomarker.
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| http://dx.doi.org/10.1016/j.neurobiolaging.2012.07.012 | DOI Listing |
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