Hippo signaling goes long range. | LitMetric

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Hippo signaling goes long range. | LitMetric

Hippo signaling goes long range.

Veronica A Codelia Kenneth D Irvine

Cell

Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.

Published: August 2012

The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.

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http://dx.doi.org/10.1016/j.cell.2012.07.020	DOI Listing

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