AI Article Synopsis
- The study examined the impact of initial and changing levels of blood pressure and LDL cholesterol on carotid intima media thickness (IMT) in 2,572 adults over six years.
- Higher baseline levels of LDL cholesterol and blood pressure were linked to increased IMT, indicating potential cardiovascular risks.
- Only changes in blood pressure, not LDL cholesterol, were significantly related to changes in IMT, highlighting the importance of monitoring blood pressure over time.
Article Abstract
Background: The effects of baseline and changes in blood pressure and low density lipoprotein (LDL) cholesterol on the carotid intima media thickness (IMT) have not been well documented.
Methods: A total of 2572 adults (mean age 53.8 years, 54.6% women) in a Taiwanese community undertook three blood pressure and LDL cholesterol examinations over 6 years. Latent growth curve modeling was used to investigate the effects of baseline and change in blood pressure and LDL cholesterol on IMT.
Results: Greater baseline LDL and blood pressure were associated with an increase in IMT (0.005 ± 0.002 mm per 1 mg/dL [p = 0.006] and 0.041 ± 0.004 mm mm Hg [p <0.0001], respectively. Change in blood pressure was associated with a significant increase in IMT (0.047 ± 0.016, P = 0.004), whilst the association between change in LDL and change in IMT was not statistically significant (0.008 ± 0.006, P = 0.20).
Conclusions: Carotid IMT was associated with baseline blood pressure and LDL cholesterol, yet only changes of blood pressure, not LDL cholesterol, were related to carotid IMT during the 6-year observation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445849 | PMC |
| http://dx.doi.org/10.1186/1471-2261-12-66 | DOI Listing |
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