Objective: The abdominal route of genitourinary fistula repair may be associated with longer term hospitalisation, hospital-associated infection and increased resource requirements. We examined: (1) the factors influencing the route of repair; (2) the influence of the route of repair on fistula closure 3 months following surgery; and (3) whether the influence of the route of repair on repair outcome varied by whether or not women met the published indications for abdominal repair.

Design: Prospective cohort study.

Setting: Eleven health facilities in sub-Saharan Africa and Asia.

Population: The 1274 women with genitourinary fistula presenting for surgical repair services.

Methods: Risk ratios (RRs) and 95% confidence intervals (95% CIs) were generated using log-binomial and Poisson (log-link) regression. Multivariable regression and propensity score matching were employed to adjust for confounding.

Main Outcome Measures: Abdominal route of repair and fistula closure at 3 months following fistula repair surgery.

Results: Published indications for abdominal route of repair (extensive scarring or tissue loss, genital infibulation, ureteric involvement, trigonal, supratrigonal, vesico-uterine or intracervical location or other abdominal pathology) predicted the abdominal route [adjusted risk ratio (ARR), 15.56; 95% CI, 2.12-114.00]. A vaginal route of repair was associated with increased risk of failed closure (ARR, 1.41; 95% CI, 1.05-1.88); stratified analyses suggested elevated risk among women meeting indications for the abdominal route.

Conclusions: Additional studies powered to test effect modification hypotheses are warranted to confirm whether the abdominal route of repair is beneficial for certain women.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470701PMC
http://dx.doi.org/10.1111/j.1471-0528.2012.03461.xDOI Listing

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