This article describes the synthesis of multifunctional nanoparticulate systems and a range of organic reactions for modifying the surface functionalities of these particles and their composites. The reactions include surface silanization, amine-azide conversion, azide-alkyne 'click' chemistry, thiol and amine click chemistry and amide coupling. In addition, we discuss a number of relevant nanoparticle preparations to exemplify the interrelationship of these reactions. This system can readily be adapted to produce a wide range of composites with different features, such as fluorescence, magnetism, plasmon resonance and multiple biofunctionalities.
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