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Case report: Accidental aconitine poisoning caused by the inappropriate use of a type of Chinese patent medicine.
Front Pharmacol
January 2025
Department of Pharmacy, Cheeloo College of Medicine, The Hospital of Shandong University, Shandong University, Jinan, Shandong, China.
Background: Compound schizonepeta fumigation lotion is a type of Chinese patent medicine for external use. It has the effect of dispelling wind, eliminating dampness, reducing swelling, and relieving pain. Clinically, it is used for anal fumigation and treatment of external hemorrhoids, anal fissures, and other diseases.
View Article and Find Full Text PDFDual Blood Purification with CytoSorb and oXiris in Managing Recurrent Septic Shock: A Case Report.
Am J Case Rep
January 2025
Department of Anesthesiology and Intensive Care, Legionowo Hospital, Military Institute of Medicine - National Research Institute, Warsaw, Poland.
BACKGROUND Extracorporeal blood purification strategies were recently developed as adjunctive treatments for sepsis. CytoSorb® is an approved medical device designed to reduce blood levels of inflammatory cytokines. The oXiris high-adsorption membrane filter is used in continuous hemofiltration adsorption.
View Article and Find Full Text PDFIn vivo toxicological evaluation of 3-benzylideneindolin-2-one: antifungal activity against clinical isolates of dermatophytes.
BMC Pharmacol Toxicol
January 2025
Department of Basic Sciences, Faculty of Allied Health Science, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
Background: Dermatophytes, the primary causative agents of superficial cutaneous fungal infections in humans, present a significant therapeutic challenge owing to the increasing prevalence of recurrent infections and the emergence of antifungal resistance. To address this critical gap, this study was designed to investigate the antifungal potential of 3-benzylideneindolin-2-one against dermatophytes and assess its in vivo toxicological profile using brine shrimp and zebrafish embryo models.
Methods: The antifungal activity of 3-benzylideneindolin-2-one was evaluated against 30 clinical isolates of dermatophyte species, including Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum gypseum, Microsporum canis, and Epidermophyton floccosum, by determining the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) using the broth microdilution method.
Neutrophil-to-lymphocyte ratio as a predictor of short- and long-term complications in pediatric burns.
Ital J Pediatr
January 2025
Department of Pediatric Surgery, La Paz Children´s University Hospital, Madrid, Spain.
Background: Neutrophil-to-Lymphocyte Ratio (NLR) has been postulated as a useful inflammatory biomarker in the prediction of complications in different pediatric diseases. Our aim is to analyze the predictive value of NLR in the development of complications in burned children, both in the short-term (need for grafting) and in the long-term (need for surgery of the sequelae).
Methods: A retrospective study was performed on burned patients under 18-years admitted to our Burn Unit between 2015 and 2021.
Evaluating the impact of ESICM 2023 guidelines and the new global definition of ARDS on clinical outcomes: insights from MIMIC-IV cohort data.
Eur J Med Res
January 2025
The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, Fujian, China.
Background: In 2023, the European Society of Intensive Care Medicine (ESICM) recommended updated criteria for acute respiratory distress syndrome (ARDS). In 2024, Matthay et al. updated the global ARDS definition in AJRCCM, titled "A New Global Definition of Acute Respiratory Distress Syndrome.
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