Objective: To investigate the effects of L-arginine (L-Arg) on acid-base balance and thromboelastograph (TEG) in rabbits after banked-blood transfusion.
Methods: Fifty New Zealand white rabbits, of which 20 were banked-blood donors, and the remaining 30 were randomly divided into 3 groups (n=10).
Control Group: hypovolemic models were made through blood loss by 20% of blood volume, and were retransfused with equal volume of banked-blood (14 days) 30 min later. Normal saline 1.2 mL/kg was given intravenously 5 min before transfusion; Sham operation group: the rabbits only received 25% L-Arg 300 mg/kg (1.2 mL/kg) intravenously at the same time-point as control group, without blood loss and banked-blood transfusion; L-Arg group: the rabbits received the same procedure as control group,equal volume of L-Arg was given as the control instead of normal saline. Blood gas /electrolyte analyses were determined before (T0) and after blood loss (T1), immediately after banked-blood transfusion (T2), 60 min (T3) and 120 min (T4) after banked-blood transfusion. TEG were checked only at T0 and T4.
Results: In control group and L-Arg group, pH values were declined after blood loss and banked-blood transfusion, and then increased after the first drop. The pH value of control group at T2 was significantly lower than that at T0 and T1 (P<0.05). Base excess (BE) values continued to decrease from T0 to T4 of the three groups, which were significantly lower at T4 than at T0 in sham operation group (P<0.05). As to the concentration of blood lactate (Lac),there were no significant differences between the three groups at T0. In sham operation group and L-Arg group, Lac decreased from T0 to T4 (P<0.05), which was significantly lower than that of control group at the same time-point (P<0.05). The TEG had no significant difference within and among the groups at T0 and T4 (P>0.05).
Conclusion: L-Arg 300 mg/kg intravenous injection can improve tissue perfusion in rabbits receiving banked-blood transfusion, while there was little effect on acid-base balance and TEG.
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