AI Article Synopsis
- Simian immunodeficiency virus (SIV) in natural hosts like African green monkeys typically causes chronic infection without severe disease symptoms.
- These monkeys maintain a healthy intestinal barrier and have lower levels of cells that can be infected.
- Research shows that memory CD4(+) T cells in the gut are a primary source of virus in the body, playing a key role in sustaining SIV levels in these monkeys.
Article Abstract
Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4(+) T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457182 | PMC |
| http://dx.doi.org/10.1128/JVI.01556-12 | DOI Listing |
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