Tissue surface as the reference arm in Fourier domain optical coherence tomography.

J Biomed Opt

University of Edinburgh, School of Engineering, Institute for Integrated Micro and Nano Systems, Faraday Building, Kings Buildings, Mayfield Road, Edinburgh EH93JL, United Kingdom.

Published: July 2012

AI Article Synopsis

  • The authors introduce a straightforward method for common-path Fourier domain optical coherence tomography (OCT) that utilizes the tissue surface as a reference arm.
  • They suggest using aluminium hydroxide powder as a diffuser, which can enhance the versatility of the technique without the need for traditional reflective elements like glass plates.
  • The proposed method significantly reduces artifacts and achieves impressive sensitivity levels of 94 dB and 97.5 dB with different CCD integration times.

Article Abstract

We present a simple method applicable to common-path Fourier domain optical coherence tomography (OCT) in which the tissue surface is used as the reference arm. We propose using aluminium hydroxide powder as a potential tissue surface diffuser to allow wider application of this method. This technique allows one to avoid placing a reference arm reflective element, such as glass plate, on tissue, and intrinsically avoids both coherent and complex conjugate mirror artifacts associated with glass plates. Aluminium hydroxide can be sprayed onto tissue using spray nozzles commonly found in endoscopes. The sensitivity of the tissue reference arm common-path OCT image is 94 dB for a 50-[micro sign]s charge-coupled device integration time, and 97.5 dB for a 200-[micro sign]s CCD integration time.

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Source
http://dx.doi.org/10.1117/1.JBO.17.7.071305DOI Listing

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