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Delayed osteomyelitis following an open ankle fracture in an immunocompetent patient.
BMJ Case Rep
January 2025
Infection Services, University Hospitals Birmingham NHS Foundation Trust, Birmingham, Birmingham, UK.
is a ubiquitous environmental fungus, and several osteomyelitis cases have been reported in recent years. We present the case of a woman in her 70s who sustained a comminuted open ankle fracture, with garden soil contamination of the wound, which was treated according to orthoplastic principles. The patient developed osteomyelitis 6 months postsurgery.
View Article and Find Full Text PDFosteomyelitis in a dog.
Can Vet J
January 2025
Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, Florida 32608, USA (Whitman); Gulf Coast Veterinary Specialists, 8042 Katy Freeway, Houston, Texas 77024, USA (Wilson); Department of Small Animal Clinical Sciences, Texas A&M School of Veterinary Medicine and Biomedical Sciences, 4474 TAMU, College Station, Texas 77843, USA (Heseltine).
Canine systemic protothecosis is an uncommon disease caused by spp., which are saprophytic algae occurring ubiquitously in nature. Infection occurs most commonly in immunocompromised animals.
View Article and Find Full Text PDF[Isolated osseous tuberculosis : Differential diagnosis of treatment refractory osteomyelitis?].
Unfallchirurgie (Heidelb)
January 2025
Klinik für Orthopädie und Unfallchirurgie, BG Klinikum Duisburg, Großenbaumer Allee 250, 47249, Duisburg, Deutschland.
We report the case of a 66-year-old female patient with a treatment refractory disorder of wound healing of the knee, who had already been treated several times surgically and with antibiotics for several months. The examination revealed a skin defect with a fistula in the region of the knee joint. The X‑ray imaging showed an extensive bony defect of unclear etiology.
View Article and Find Full Text PDFTargeting ClpP: Unlocking a novel therapeutic approach of isochlorogenic acid A for methicillin-resistant Staphylococcus aureus-infected osteomyelitis.
Microbiol Res
December 2024
College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun 130117, China. Electronic address:
A medical predicament has led to extensive drug resistance in methicillin-resistant Staphylococcus aureus (MRSA), and the complexity of treatment has increased exponentially with the induction of osteomyelitis. In view of the severe situation and the potential of bacterial antivirulence strategies, this study focused on the key virulence factor caseinolytic protease (ClpP) of S. aureus to identify new strategies against MRSA-induced osteomyelitis.
View Article and Find Full Text PDFFactors associated with treatment response in chronic nonbacterial osteomyelitis at a single center: a retrospective cohort study.
Pediatr Rheumatol Online J
January 2025
Division of Pediatric Rheumatology, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA, 98105, USA.
Background: NSAIDs are commonly used as first line therapy in chronic nonbacterial osteomyelitis (CNO) but are not effective for all patients. The objective of this study was to identify clinical variables associated with NSAID monotherapy response versus requiring second-line medication in a single-center cohort of patients with CNO.
Methods: The charts of children with CNO who attended a CNO clinic at a quaternary care center between 1/1/05 and 7/31/21 were retrospectively reviewed.
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