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The full range of ophthalmological clinical manifestations in systemic lupus erythematosus.
Front Ophthalmol (Lausanne)
January 2023
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Purpose: To determine the full range of ophthalmological clinical manifestations in systemic lupus erythematosus (SLE) and to compare the systemic features associated with them.
Methods: Files of 13 patients with ocular SLE ( 20 eyes) diagnosed as per the American College of Rheumatology (ACR) 2012 revised criteria were retrospectively reviewed.
Results: The following clinical manifestations were found: keratoconjunctivitis sicca ( three patients), anterior uveitis associated with an inflammatory pseudo-tumor orbital mass ( one patient, one eye), episcleritis and periorbital edema ( one patient, two eyes), posterior scleritis ( one patient, two eyes), bilateral papillary edema in the context of idiopathic intracranial hypertension ( one patient, one eye), inflammatory optic neuritis ( one patient, one eye), and lupus retinopathies with varying degrees of capillary occlusions mainly arteriolar ( seven patients, 13 eyes) and larger arteries or veins (retinal arteries occlusions and retinal veins occlusions) ( one patient, two eyes).
[Orbital pseudotumor - current state of knowledge].
Wiad Lek
August 2020
Klinika Neurologii, Uniwersytet Medyczny w Lublinie, Lublin, Polska.
The orbital pseudo-tumor is an orbital inflammatory disease of unknown origin that can affect all the anatomical structures that make up the orbit. The diagnosis is based on the assessment of clinical symptoms, imaging tests and the exclusion of other possible causes. Glucocorticosteroids are used for treatment, but other immunosuppressants as well as biological treatments can be used.
View Article and Find Full Text PDFMagnetic resonance imaging indicator of the causes of optic neuropathy in IgG4-related ophthalmic disease.
BMC Med Imaging
June 2019
Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong'an Road, Xicheng District, Beijing, 100050, People's Republic of China.
Background: The following study investigates the involvement of optic neuropathy in IgG4-related ophthalmic diseases (IgG4-ROD) based on the magnetic resonance imaging (MRI) data, and different imaging features of IgG4-ROD related optic neuropathy related to other orbital diseases.
Methods: This retrospective study included 225 patients with IgG4-RD admitted at two ophthalmology centers between January 2014 and December 2017. Twenty-six patients had both pre-therapeutic orbital MRI and optic never injury.
Neurologic Features of Immunoglobulin G4-Related Disease.
Rheum Dis Clin North Am
November 2017
Rheumatology Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:
Immunoglobulin G4-related disease (IgG4-RD) can involve nearly any organ system, including the central and peripheral nervous systems. IgG4 antibodies are not known to play a primary etiologic role in disease. IgG4-RD must be distinguished from a growing number of immune-mediated conditions in which IgG4 autoantibodies contribute directly to pathophysiology.
View Article and Find Full Text PDF[A rapidly progressive orbital tumor in a seven-year-old girl revealing a primitive systemic vasculitis].
Ann Pathol
December 2014
Centre de pathologie Est, groupement hospitalier Est, 59, boulevard Pinel, 69500 Bron, France.
Orbital tumor lesions in pediatric population encompass a wide range of pathological processes, which are very different in etiology and prognosis. They usually require an emergency in histological diagnosis because of their quick growth. Beside malignant and benign tumors, the inflammatory pseudo-tumors group included dysimmune orbital involvement secondary to systemic vasculitis such as granulomatosis with polyangiitis (ex-Wegener's granulomatosis).
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