AI Article Synopsis
- The coexistence of Crohn's disease (CD) and primary sclerosing cholangitis (PSC) is rare, but diagnosing it can be challenging due to potential asymptomatic presentation of PSC.
- All patients with CD should undergo liver function tests to screen for PSC, as there is a risk of increased malignancy and a poor long-term prognosis in these cases.
- Management strategies should include regular colonoscopies, liver imaging, and possibly liver transplantation, as current treatments for CD with PSC are not effective.
Article Abstract
The comorbidity of Crohn's disease (CD) and primary sclerosing cholangitis (PSC) is uncommon. Diagnosing such patients can be difficult, as illustrated by the following case. The combination of CD and PSC should be considered in patients with CD who have abnormal liver function. Because patients with PSC often present asymptomatically, all patients with CD should be screened for PSC by checking serum liver tests. Review of the literature suggests that there is an increased potential in these patients for the development of malignancy and long-term prognosis is poor. We conclude that patients diagnosed with a combination of CD and PSC should be managed with periodic colonoscopy, CA 19-9 investigation, early liver and bowel imaging, and liver biopsy. The treatment of CD associated with PSC remains unsatisfactory and the possibility of liver transplantation should be considered.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2169/internalmedicine.51.7583 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!