AI Article Synopsis
Article Abstract
Four kinds of symmetrically branched oligoglyceryl trimeric (BGL003)-paclitaxel conjugates and a corresponding heptameric (BGL007) conjugate were synthesized. Molecular weights of all the compounds were less than two times that of paclitaxel. The anti-tumor activity of the most water-soluble BGL003 conjugate was examined and found to be preserved in spite of the chemical modification that is displacement of the N3'-debenzoyl residue with the BGL003 succinyl residue.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmc.2012.07.031 | DOI Listing |
Publication Analysis
Top Keywords
synthesis paclitaxel-bgl
4
paclitaxel-bgl conjugates
4
conjugates kinds
4
kinds symmetrically
4
symmetrically branched
4
branched oligoglyceryl
4
oligoglyceryl trimeric
4
trimeric bgl003-paclitaxel
4
bgl003-paclitaxel conjugates
4
conjugates corresponding
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!