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| http://dx.doi.org/10.1073/pnas.1212463109 | DOI Listing |
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Short-Term Culture of Human Hyalocytes Retains Their Initial Phenotype and Displays Their Contraction Abilities.
Cells
November 2024
Surgical Retina Research Unit, IRCCS-Fondazione Bietti, 00184 Rome, Italy.
Background: Hyalocytes are the main vitreal cell types with critical functions in health and vitreoretinal diseases. Our aim was to develop cultures of human hyalocytes and verify the retention of their initial cellular features after 3 and 6 days of culturing (3 d and 6 d) by analyzing and comparing a few morphological and functional parameters.
Methods: Vitreous samples (n = 22) were collected and vitreous cells and bead-enriched hyalocytes were developed and compared (3 d vs.
Immune drivers of pain resolution and protection.
Nat Immunol
December 2024
F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Immune cells are involved in the pathogenesis of pain by directly activating or sensitizing nociceptor sensory neurons. However, because the immune system also has the capacity to self-regulate through anti-inflammatory mechanisms that drive the resolution of inflammation, it might promote pain resolution and prevention. Here, we describe how immune cell-derived cytokines can act directly on sensory neurons to inhibit pain hypersensitivity and how immune-derived endogenous opioids promote analgesia.
View Article and Find Full Text PDFThe involvement of endogenous melatonin in LPS-induced M1-like macrophages and its underlying synthesis mechanism regulated by IRF3.
Exp Cell Res
November 2024
School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China. Electronic address:
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- * The study found that the lipopolysaccharide (LPS) treatment, which normally promotes M1 polarization, actually increases endogenous MLT secretion in macrophages, indicating a possible protective mechanism.
- * Results show that LPS activates the TLR4/TRIF pathway leading to MLT secretion, with MLT helping to inhibit M1 polarization and reduce apoptosis in macrophages, highlighting its role in immune response and pathogen clearance.
Cordycepin mitigates dextran sulfate sodium-induced colitis through improving gut microbiota composition and modulating Th1/Th2 and Th17/Treg balance.
Biomed Pharmacother
November 2024
Department of Tumor Biological Treatment, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China; Institute of Cell Therapy, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China. Electronic address:
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- * In an experiment with mice, cordycepin treatment significantly reduced signs of colitis, improved overall health, and positively affected gut bacteria composition after a week of administration.
- * The findings suggest that cordycepin effectively alleviates colitis by promoting a healthy balance between gut microbiota and the immune system's response.
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