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Predictors of Cryptococcus gattii clinical presentation and outcome: An international study.
Clin Infect Dis
January 2025
Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Background: Infection by Cryptococcus gattii can lead to pulmonary or central nervous system (CNS) disease, or both. Whether site of infection and disease severity are associated with C. gattii species and lineages or with certain underlying medical conditions, or both is unclear.
View Article and Find Full Text PDFEarly Onset of Post-Infectious Inflammatory Response Syndrome (PIIRS) in a Previously Healthy, HIV-Negative Paediatric Patient With Cryptococcus gattii Meningitis: A Case Report.
J Paediatr Child Health
January 2025
Infection Management, QCH and CHQ Clinical Unit, The University of Queensland, South Brisbane, Queensland, Australia.
Divergent paths: gene evolution in Cryptococcus and implications for pathogenicity.
Curr Med Mycol
April 2024
Department of Biotechnology, College of Science, University of Anbar, Ramadi, Anbar, Iraq.
Background And Purpose: and are highly virulent species that cause diseases, such as meningoencephalitis and pulmonary infections. The gene predominantly determines the virulence of the pathogenic species. This study aimed to examine in both pathogenic and non-pathogenic species.
View Article and Find Full Text PDFAn immunoinformatics and extensive molecular dynamics study to develop a polyvalent multi-epitope vaccine against cryptococcosis.
PLoS One
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Faculty of Biotechnology and Genetic Engineering, Sylhet Agricultural University, Sylhet, Bangladesh.
Cryptococcosis is a lethal mycosis instigated by the pathogenic species Cryptococcus neoformans and Cryptococcus gattii, primarily affects the lungs, manifesting as pneumonia, and the brain, where it presents as meningitis. Mortality rate could reach 100% if infections remain untreated in cryptococcal meningitis. Treatment options for cryptococcosis are limited and and there are no licensed vaccines clinically available to treat or prevent cryptococcosis.
View Article and Find Full Text PDFEffect of insertion of intein to Cryptococcus amylolentus, a nonpathogenic fungus closely related to causative agents of cryptococcosis.
Microb Pathog
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Department of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, 1703 E Mabel St, Tucson, AZ, 85721-0207, USA; The BIO5 Institute, The University of Arizona, Tucson, AZ, 85721, USA; Biological Chemistry Program, Department of Chemistry and Biochemistry, College of Science & College of Medicine, The University of Arizona, Tucson, AZ, 85721, USA; Department of Molecular & Cellular Biology, College of Science, The University of Arizona, Tucson, AZ, 85721, USA. Electronic address:
Inteins are mobile elements within a host protein, with flanking exteins. Autocleavage of intein results in the fusion of exteins, leading to activation of protein. The presence of intein is species dependent.
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