The total of 186 metastatic skin melanoma patients with regional lymph nodes involvement (locoregional stage) received neoadjuvant chemotherapy and irradiation followed by extended lymphodissection. This therapy allowed obtaining favorable overall survival in most patients. Social aspect of the problem should also be noted - the tenacity in treatment of unfavorable prognosis patients using all treatment modalities available allows giving back the hope and extending the lifespan of many patients.
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