The use of swarms of nanobots to perform seemingly miraculous tasks is a common trope in the annals of science fiction.1 Although several of these remarkable feats are still very much in the realm of fiction, scientists have recently overcome many of the physical challenges associated with operating on the small scale and have generated the first generation of autonomous self-powered nanomotors and pumps. The motors can be directed by chemical and light gradients, pick up and deliver cargo, and exhibit collective behavior.
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http://dx.doi.org/10.1002/anie.201202044 | DOI Listing |
Compr Psychoneuroendocrinol
February 2024
Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, 10032, USA.
This is the story of my 50-year career in medicine and research, and the people who influenced and helped me most along the way. I recount the way in which I became interested in oxytocin early in my career as a child psychiatrist, and how it led me back to Columbia University, my alma mater, to study oxytocin's role in mother-child innate behaviors. I recount how oxytocin/oxytocin receptor signaling was central to my basic and clinical research and present a new theory on mother-infant emotional behaviors that challenges 400 years of brain-centric science.
View Article and Find Full Text PDFGenes Dis
March 2024
Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
NLRP3 inflammasome, an intracellular multiprotein complex, can be activated by a range of pathogenic microbes or endogenous hazardous chemicals. Its activation results in the release of cytokines such as IL-1β and IL-18, as well as Gasdermin which eventually causes pyroptosis. The activation of NLRP3 inflammasome is under strict control and regulation by numerous pathways and mechanisms.
View Article and Find Full Text PDFWiley Interdiscip Rev Nanomed Nanobiotechnol
November 2021
Centre for Nano Science and Engineering, Indian Institute of Science, Bangalore, India.
The idea of "fantastic voyagers" carrying out medical tasks within the human body has existed as part of popular culture for many decades. The concept revolved around a miniaturized robot that can travel inside the human body and perform complicated functions such as surgery, navigation of otherwise inaccessible biological environments, and delivery of therapeutics. Since the last decade, significant developments have occurred in this arena that are yet to enter mainstream biomedical practises.
View Article and Find Full Text PDFGastrointest Endosc
March 2021
Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
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