The root of Hemidesmus indicus R. Br., commonly known as Indian Sarsaparilla, is used traditionally to treat a wide variety of illnesses including rheumatism, leprosy, impotence, urinary tract and skin infections. The anticancer, antioxidant, anti-inflammatory, antipyretic, analgesic, antimicrobial, antidiabetic, hepatoprotective, cardioprotective, renoprotective, neuroprotective and immunomodulatory properties of H. indicus have been investigated in numerous in vivo and in vitro studies. Among these, the antioxidant and antimicrobial activity was well documented. This review details the phytochemistry and therapeutic applications of H. indicus root.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ptr.4788 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
From nature's bounty to drug discovery: Leveraging phytochemicals and molecular approaches to combat multi-drug-resistant (MDR) tuberculosis.
Indian J Tuberc
July 2024
Khalsa College of Pharmacy, H.No 21a, Lane No 4, Chheharta, Amritsar, Punjab, 143002, India.
Article Synopsis
- Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant global health issue, with specific regions like South-East Asia, Africa, and the Western Pacific reporting the highest new cases.
- The rise of multi-drug-resistant (MDR) TB has prompted researchers to explore natural alternatives, such as phytochemicals, which could offer a safer and more effective treatment option than current synthetic drugs.
- Traditional medicinal systems like Ayurveda and Siddha utilize various plants known for their beneficial compounds, and ongoing research focuses on mapping molecular approaches to enhance the effectiveness of these natural remedies against MDR TB.
Optimization of ultrasound-assisted extraction of bioactive chemicals from (L.) R.Br. using response surface methodology and adaptive neuro-fuzzy inference system.
Food Sci Biotechnol
January 2024
Department of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil, 626126 India.
Unlabelled: This study was designed to optimize the ultrasound-assisted extraction (UAE) of bioactive chemicals from (L.) R.Br.
View Article and Find Full Text PDFEvaluation of the Efficacy of a Neem Extract-Based Herbal Ointment, Herbal Antioxidant, and Propolis on Oxidative Stress Related to Oral Ulcers: An Interventional Animal Study.
Cureus
November 2023
Department of Conservative Dentistry and Endodontics, College of Dentistry, Jazan University, Jazan, SAU.
Unlabelled: Traumatic oral ulcers are one of the most commonly encountered oral ulcers. Their healing may be delayed due to factors like the presence of opportunistic infectious microbes in the oral cavity, secondary trauma from sharp edges of teeth, and the systemic condition of the patient.
Aim: To compare the efficacy of a newly developed neem extract containing herbal ointments (propolis and in enhancing the wound contraction of traumatic oral ulcers and to determine the relationship between oxidative stress and oral ulcers.
Antibacterial activity of 2-hydroxy-4-methoxybenzaldehyde and its possible mechanism against Staphylococcus aureus.
J Appl Microbiol
July 2023
MOST-USDA Joint Research Center for Food Safety, School of Agriculture and Biology, and State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, China.
Article Synopsis
- Staphylococcus aureus, particularly methicillin-resistant strains (MRSA), poses a significant global health challenge, prompting the search for effective natural antibacterial agents.
- The study investigates the antibacterial properties of 2-hydroxy-4-methoxybenzaldehyde (HMB) from Hemidesmus indicus, revealing it has a minimum inhibitory concentration of 1024 µg/ml and effectively disrupts MRSA growth by targeting the cell membrane.
- HMB demonstrates strong antibiofilm activity, removing around 80% of established MRSA biofilms, and enhances the effectiveness of tetracycline, suggesting its potential as a basis for new antibacterial drug development.
An In Silico Molecular Modelling-Based Prediction of Potential Keap1 Inhibitors from (L.) R.Br. against Oxidative-Stress-Induced Diseases.
Molecules
June 2023
Department of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil 626126, India.
The present study investigated the antioxidant potential of aqueous methanolic extracts of (L.) R.Br.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!