Biomimetic aerobic oxidation of amino alcohols to lactams.

Chemistry

Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91, Stockholm, Sweden.

Published: September 2012

The right path: N-protected amino alcohols undergo aerobic and biomimetic oxidation to the corresponding lactams in the presence of a ruthenium catalyst and a combination of electron-transfer mediators under air (see scheme). The reaction was used for the synthesis of five-, six-, and seven-, membered lactams and showed good tolerance to a number of N-protecting groups.

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.201202080DOI Listing

Publication Analysis

Top Keywords

amino alcohols
8
biomimetic aerobic
4
aerobic oxidation
4
oxidation amino
4
alcohols lactams
4
lactams path
4
path n-protected
4
n-protected amino
4
alcohols undergo
4
undergo aerobic
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!