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Patient With Post-operative Recurrent Pancreatic Cancer Treated With Cone Beam Computed Tomography-Guided Stereotactic Adaptive Radiotherapy: A Case Report.
Cureus
December 2024
Radiation Oncology, Washington University School of Medicine, Saint Louis, USA.
CT-guided adaptive radiotherapy (ART) for the treatment of pancreatic adenocarcinoma is rapidly increasing and has been shown to provide advanced treatment tools comparable to magnetic resonance imaging (MRI)-guided adaptive therapy. Here, we provide the first case report of a local pancreatic recurrence treatment after definitive resection using cone beam computed tomography (CBCT)-guided ART (CT-guided ART) enabled by HyperSight imaging (Varian Medical Systems, Inc., Palo Alto, CA, USA) for daily delineation of organs-at-risk (OARs) and target to improve the quality of online ART.
View Article and Find Full Text PDFImmunogenicity, Safety, and Reactogenicity of Concomitant Administration of the Novavax Vaccine against Omicron XBB.1.5 (NVX-CoV2601) and a 20-valent Pneumococcal Conjugate Vaccine in Adults Aged ≥60 Years: A Randomised, Double-blind, Placebo-controlled, Non-inferiority Trial.
J Infect
January 2025
Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. Electronic address:
Objectives: There is conflicting evidence as to whether the combined administration of two vaccines can lead to poorer immunogenicity and reactogenicity. The co-administration of the Omicron-adapted COVID-19 vaccine from Novavax (NVX-CoV2601) and a 20-valent pneumococcal conjugate vaccine (PCV20) has not been previously investigated.
Methods: In this randomised, double-blind, placebo-controlled, non-inferiority trial, immunocompetent participants aged ≥60 years were randomised in a 1:1:1:1 ratio to four groups: NVX-CoV2601 plus PCV20 (combination group); NVX-CoV2601 plus placebo (NVX-only group); PCV20 plus placebo (PCV20-only group); or placebo plus placebo (placebo group).
Fracture resistance and marginal fit of three different overlay designs using advanced zirconia-reinforced lithium disilicate CAD/CAM material.
BMC Oral Health
January 2025
Department of Conservative Dentistry, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Background: Conservative dentistry introduced modern restoration designs, contributing to the greater use of partial-coverage ceramic restorations. New strong bondable ceramic materials made fabricating partial coverage ceramic restorations easier to restore the badly destructed teeth.
Aim Of The Study: This study investigated the impact of three distinct overlay preparation designs on the marginal fit (both before and after thermal aging) and the fracture resistance of overlay restorations fabricated using advanced zirconia-reinforced lithium disilicate (ALD) CAD/CAM glass-ceramic blocks.
Identification of Ancylostoma caninum in Domestic Dogs from Ecuador via Various Techniques.
Med Sci Monit
January 2025
Institute of Invertebrates, Fundación Miguel Lillo, San Miguel de Tucumán, Argentina.
BACKGROUND Ancylostoma caninum is a soil-borne, soil-transmitted helminth with infective larvae and produces cutaneous larva migrans in humans. The objective of this study was to confirm the presence of A. caninum in domestic dogs from the urban-marginal and rural sectors of the Ecuadorian coast through morphometry, culture, and molecular techniques.
View Article and Find Full Text PDFBackbone extraction through statistical edge filtering: A comparative study.
PLoS One
January 2025
LIB, Université de Bourgogne, Franche-Comté, Dijon, France.
The backbone extraction process is pivotal in expediting analysis and enhancing visualization in network applications. This study systematically compares seven influential statistical hypothesis-testing backbone edge filtering methods (Disparity Filter (DF), Polya Urn Filter (PF), Marginal Likelihood Filter (MLF), Noise Corrected (NC), Enhanced Configuration Model Filter (ECM), Global Statistical Significance Filter (GloSS), and Locally Adaptive Network Sparsification Filter (LANS)) across diverse networks. A similarity analysis reveals that backbones extracted with the ECM and DF filters exhibit minimal overlap with backbones derived from their alternatives.
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