Purpose: To restore functional stability of the knee joint and to prevent secondary injuries to the cartilage and menisci are the main goals of an anterior cruciate ligament (ACL) reconstruction. Functional stability can be assessed by health-related quality of life questionnaires, but characterising differences between a satisfactory and non-satisfactory result can be challenging.
Methods: The aim of this study based on the Swedish National Knee Ligament Register was to find predictors for a satisfactory result defined as functional recovery (FR) or a non-satisfactory result defined as treatment failure (TF), with special emphasis on waiting time before surgery and additional injuries. FR was defined as a Knee Osteoarthritis Outcome Score (KOOS) above: 90 for Pain, 84 for Symptoms, 91 for ADL, 80 for Sport/Rec and 81 for quality of life (QoL). TF was defined as a KOOS, QoL < 44.
Results: A complete KOOS was available for 41.4 % of a cohort of 8,584 patients 2 years after the ACL reconstruction. Of all patients, 19.7 % were FR and 28.9 % were TF. Male gender was a predictor for FR. Previous surgery of the menisci and a patella graft was predictors for TF and negative predictors for FR. A medial meniscus suture or resection at the time of reconstruction was a predictor for TF. Waiting time was a predictor for medial meniscus and cartilage injury at the time of reconstruction.
Conclusions: Functional recovery after an ACL reconstruction can be achieved; gender and additional injuries are important predictors for a functional recovery. To time surgery early, that is, before recurring giving ways has occurred is essential to decrease additional injuries and increase the chance of functional recovery.
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http://dx.doi.org/10.1007/s00167-012-2162-8 | DOI Listing |
J Perianesth Nurs
January 2025
Medical Faculty, Department of Anesthesia and Reanimation, Giresun Üniversitesi, Giresun, Türkiye. Electronic address:
Purpose: The aim in the present study was to evaluate the effects of chewing postoperative xylitol gum on gastrointestinal functional recovery after laparoscopic cholecystectomy.
Design: A three-arm randomized controlled trial.
Methods: After a baseline assessment, participants were randomly assigned in three groups.
Semin Immunopathol
January 2025
Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Metabolic flexibility is key for the function of myeloid cells. Arginine metabolism is integral to the regulation of myeloid cell responses. Nitric oxide (NO) production from arginine is vital for the antimicrobial and pro-inflammatory responses.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Optimal fluid strategy for laparoscopic donor nephrectomy (LDN) remains unclear. LDN has been a domain for liberal fluid management to ensure graft perfusion, but this can result in adverse outcomes due to fluid overload. We compared postoperative outcome of living kidney donors according to the intraoperative fluid management.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, People's Republic of China. Electronic address:
After spinal cord injury (SCI), reactive astrocytes in the injured area are triggered after spinal cord injury (SCI) and to polarize into A1 astrocytes with a proinflammatory phenotype or A2 astrocytes with an anti-inflammatory phenotype. Monopolar spindle binder 2 (MOB2) induces astrocyte stellation, maintains cell homeostasis, and promotes neurite outgrowth; however, its role in the phenotypic transformation of reactive astrocytes remains unclear. Here, we confirmed for the first time that MOB2 is associated with A1/A2 phenotypic switching in reactive astrocytes following SCI in mice.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Chemistry and Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:
A vast sum of fish waste is being annually discarded by marine fishing industries imposing serious environmental pollution concerns. However, these aquatic discarded matters are captivating sources of collagen, a fibrous protein with eminent social and economic relevance. Collagen is conventionally recovered using outdated complex processes requiring many reagents, multiple steps, and extended periods.
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