Purpose: Although the efficacy of selective neck dissection (SND) in the management of a node-negative neck is established, its utility in the management of node-positive disease remains controversial. The objective of this study was to evaluate the oncologic safety of SND in the management of N1/N2 oral cavity squamous cell carcinoma.
Materials And Methods: From a prospectively collected electronic database of patients with oral cavity cancer, a retrospective analysis was conducted of patients with nonrecurrent, clinical, and/or pathologic N1/N2 oral cavity squamous cell carcinoma who underwent SND of levels I to III/IV. The patients were stratified into 2 groups: clinical N0 but pathologic N1/N2 (cN0-pN1/N2) and clinical N1/N2 (cN1/N2). The primary outcome variable of the study was the ipsilateral regional recurrence rate. Categorical data were analyzed by the 2-sided Fisher exact test, and 3-year Kaplan-Meier ipsilateral regional control rate, regional recurrence-free survival, disease-free survival, and overall survival were estimated.
Results: Forty-nine patients constituted the study sample, with 37 patients in the cN1/N2 group and 12 patients in the cN0-pN1/N2 group. During the follow-up period of 3 years, 2 patients (∼4%) developed ipsilateral neck recurrence, and these patients were in the cN1/N2 group. The 3-year Kaplan-Meier ipsilateral regional control rate was 95%.
Conclusions: SND may produce a satisfactory ipsilateral regional control rate in patients with early-stage node-positive oral squamous cell carcinoma. A prospective, randomized clinical trial comparing SND with modified radical neck dissection may be required for a categorical conclusion of these findings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.joms.2012.06.181 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fecal metabolomic analysis of the role of gut microbiota and short-chain fatty acids in the therapeutic mechanism of Timosaponin AIII in Sjögren's syndrome.
Clin Rheumatol
January 2025
Department of Rheumatology, Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Introduction/objectives: Sjogren's syndrome (SS) is a chronic inflammatory and difficult-to-treat autoimmune disease. Timosaponin AIII (TAIII), a plant-derived steroidal saponin, effectively inhibits cell proliferation, induces apoptosis, and exhibits anti-inflammatory properties. This study explored the mechanisms of action of TAIII in SS treatment by studying gut microbiota and short-chain fatty acids (SCFAs) using fecal metabolomics.
View Article and Find Full Text PDFInfluence of the Type of Bulk-Fill, Resin-Based Composite on Internal Adaptation in Class V Restorations.
J Coll Physicians Surg Pak
January 2025
Department of Stomatology, The Second People's Hospital of Hefei and Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China.
Objective: To investigate the effects of bulk-fill, resin-based composite types (high or low viscosity) on the internal adaptation of Class V restorations.
Study Design: Experimental study. Place and Duration of the Study: Hefei Stomatological Hospital, Hefei, China, from October 2022 to December 2023.
Effect of Irrigation Solution Temperature on Bioceramic Sealer Bond Strength.
Med Sci Monit
January 2025
Department of Endodontics, Faculty of Dentistry, Dicle University, Diyarbakir, Turkey.
BACKGROUND Different temperature conditions can affect the efficiency of irrigation solutions and consequently the ability of canal sealers to bond to root canal walls. The aim of this endodontic study was to evaluate the effect of irrigation solutions at different temperatures on the bond strength of a bioceramic-based root canal sealer. MATERIAL AND METHODS Root canal preparations were completed through irrigation with the following solutions: Group 1 was irrigated with 5 ml NaOCl (sodium hypochlorite) +5 ml EDTA (Ethylenediamine tetra-acetic acid) (22°C); Group 2 was irrigated with 5 ml NaOCl +5 ml EDTA (37°C); Group 3 was irrigated with 5 ml NaOCl +5 ml GA (Glycolic acid) (22°C); Group 4 was irrigated with 5 ml NaOCl +5 ml GA (37°C), Group 5 was irrigated with 20 ml Dual Rinse® HEDP (Etidronate) - NaOCl mixture (22°C); and Group 6 was irrigated with 20 ml of Dual Rinse® HEDP mixture (37°C).
View Article and Find Full Text PDFUndifferentiated pleomorphic sarcoma in the maxillary sinus: a case report.
J Med Case Rep
January 2025
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Background: Undifferentiated pleomorphic sarcoma, previously called malignant fibrous histiocytoma, is a type of malignant mesenchymal tumor (sarcoma) of soft tissue and sometimes bone. It is uncommon in the oral cavity and very sporadic in the maxillary sinus. Microscopic diagnosis of this malignancy in the maxillary sinus can be very challenging, because there is a range of features that may overlap with other benign and malignant tumors.
View Article and Find Full Text PDFConstruction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines.
Virol J
January 2025
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361102, PR China.
Coxsackievirus A6 (CVA6) has emerged as a major pathogen causing hand, foot and mouth disease (HFMD) outbreaks worldwide. The CVA6 epidemic poses a new challenge in HFMD control since there is currently no vaccine available against CVA6 infections. The Vero cell line has been widely used in vaccine production, particularly in the preparation of viral vaccines, including poliovirus vaccines and EV71 vaccines.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!