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Setpoint weighted PI-FOPD cascade controllers synthesis for unstable time-delayed processes satisfying prespecified safety margins.
ISA Trans
December 2024
Department of Electrical Engineering, Tungnan University, No. 152, Section 3, Peishen Rd., Shenkeng Dist., New Taipei 222, Taiwan. Electronic address:
This article introduces a novel setpoint weighted PI-FOPD (SWPI-FOPD) cascade controller with a prefilter. It further describes a four-stage design strategy that sequentially enhances tracking responses, reduces overshoot, and ensures robustness for unstable time-delayed (UTD) processes. The controller applies to integrating and non-integrating UTD processes of any order and does not necessitate model order reduction or delay approximation.
View Article and Find Full Text PDFComputational modelling of cardiac control following myocardial infarction using an in silico patient cohort.
J Physiol
December 2024
Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
Loss of cardiac physiological function following myocardial infarction (MI) is accompanied by neural adaptations in the baroreflex that are compensatory in the short term, but then become associated with long-term disease progression. One marker of these adaptations is decreased baroreflex sensitivity, a strong predictor of post-MI mortality. The relative contributions of cardiac remodelling and neural adaptation in the sensory, central brainstem and peripheral ganglionic loci to baroreflex sensitivity changes remain underexplored.
View Article and Find Full Text PDFLINC01094 promotes gastric cancer through dual targeting of CDKN1A by directly binding RBMS2 and HDAC1.
Biol Direct
December 2024
Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi, 214062, Jiangsu Province, China.
Background: Accumulating studies have focused on long noncoding RNAs (lncRNAs) because of their regulatory effects on multiple cancers. However, the biological functions and molecular mechanisms of lncRNAs in gastric cancer (GC) remain to be elucidated in depth.
Methods: Long intergenic nonprotein coding RNA 1094 (LINC01094), a differentially expressed lncRNA between GC tissues and adjacent normal tissues, was identified.
Upper airway collapsibility during rapid eye movement sleep tracks the response to upper airway surgery for obstructive sleep apnea.
Clin Exp Otorhinolaryngol
December 2024
Department of Public Health, China Medical University, Taichung, Taiwan.
Objectives: Endotype-based intervention has shown promise in treatment for patients with obstructive sleep apnea, and upper airway surgery is an important therapeutic option. However, the response to surgery varies among patients with obstructive sleep apnea. This study aims to examine changes in endotypic traits following upper airway surgery and their association with surgical outcome.
View Article and Find Full Text PDFAre noradrenergics combined with antimuscarinics the future pharmacologic treatment for obstructive sleep apnea? A systematic review and meta-analysis of randomized controlled trials.
Sleep Breath
December 2024
Faculty of Medicine, Assiut University, Assiut, Egypt.
Purpose: Noradrenergics and antimuscarinics have been proposed as future pharmacotherapy for obstructive sleep apnea (OSA). However, the available randomized controlled trials (RCTs) showed heterogeneous results regarding the safety and efficacy of the combined regimen in OSA. Therefore, we performed this meta-analysis from the published RCTs to clarify this conflicting evidence.
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